Single-cell transcriptomic analysis defines hair cell and supporting cell types in the zebrafish inner ear, and reveals homologies with cells in the mammalian ear.
Genetic and microscopy analyses identify a programmed cell death mechanism that kills a cell subpopulation in a bacterial biofilm where oxygen is limiting, thereby promoting dispersion of newborn motile cells through the action of DNA released by dead cells.
Hudson W Coates, Isabelle M Capell-Hattam ... Andrew J Brown
Hypoxic accumulation of squalene, the substrate of squalene monooxygenase, triggers its proteasomal truncation to a constitutively active variant that preserves downstream sterol synthesis.
Cayla E Jewett, Bailey L McCurdy ... Chad G Pearson
Trisomy 21, the genetic cause of Down syndrome, produces elevated centrosome protein levels reducing intracellular trafficking to and from the centrosome thereby delaying primary ciliogenesis, ciliary signaling, and mouse cerebellar development.
Philippa Anne Johnson, Tessel Blom ... Hinze Hogendoorn
To accurately represent object position in real time, the human visual system predictively encodes the location of moving objects, compensating for the time required for transmission and processing of information.
V2 and V4 contain orthogonal maps of orientation and spatial frequency, which indicates a fundamental principle of functional mapping across the cortical surface that ensures and optimizes the complete representation of all combinations across two coding dimensions.
Biochemical and genetic approaches reveal how the focal adhesion protein kindlin-2 controls the liver development and homeostasis by reducing inflammation.
A novel method of recording neural activity from the rodent medial prefrontal cortex reveals that the medial prefrontal cortex is composed of functionally distinct subregions that process economic decision information differentially along a dorso-ventral gradient.
