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    1. Evolutionary Biology
    2. Genetics and Genomics

    Faroese whole genomes provide insight into ancestry and recent selection

    Iman Hamid, Ólavur Mortensen ... Noomi O Gregersen
    Present-day Faroese genomes reveal ancestry, bottleneck history, and signatures of selection, and offer a foundation for understanding the genetic architecture of health and disease in this North Atlantic founder population.
    1. Microbiology and Infectious Disease

    A rapid transfer of virions coated with heparan sulfate from the ECM to CD151 defines an early step in the human papillomavirus infection cascade

    Annika Massenberg, Yahya Homsi ... Thorsten Lang
    In an assay focusing on active virus recruitment rather than passive binding, STED microscopy reveals early association of virions to CD151, indicating its early involvement in viral entry platforms formation.
    1. Neuroscience

    Methylphenidate enhances or impairs the cognitive control of Pavlovian bias depending on working memory capacity

    Dirk EM Geurts, Hanneke EM den Ouden ... Roshan Cools
    Catecholaminergic modulation by methylphenidate affects appetitive and aversive Pavlovian biases of approach and avoidance in humans depending on individual differences in working memory capacity.
    1. Neuroscience

    Hippocampal representations differentiate reactive and anticipatory responses during foraging under threat

    Chelsey C Damphousse, Olivia L Calvin, A David Redish
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Biochemistry and Chemical Biology

    More than just a passive brick in the wall: the nucleosome facilitates DNA polymerase β activity in linker DNA and its PARP-dependent regulation in the BER pathway choice

    Danil M Shtanov, Tatyana A Kurgina ... Olga I Lavrik
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Neuroscience

    Glutamate receptor composition at Drosophila neuromuscular junctions depends on developmental stage and muscle identity

    Anne Sustar, Chengjie Qiu ... John C Tuthill
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Structural Biology and Molecular Biophysics

    Myristoylation licenses disordered viral VP4 protein to anchor to and perforate the membrane through phase separation

    Sichao Huang, Fengzhen Deng ... Bin Sun
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Neuroscience

    Human decision-makers terminate evidence accumulation using flexible decision rules

    Ishan Kalburge, Alice Dallstream ... Joshua I Gold
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Neuroscience

    Dual-feature selectivity enables bidirectional coding in visual cortical neurons

    Nikos Karantzas, Katrin Franke ... Andreas Tolias
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    The DBD-α4 helix of EWSR1::FLI1 is required for GGAA microsatellite binding that underlies genome regulation in Ewing sarcoma

    Ariunaa Bayanjargal, Cenny Taslim ... Emily Rose Theisen
    A discrete helix in the fusion oncoprotein DNA binding domain shifts binding preferences toward long and dense GGAA repeats, which promotes transcriptional hub formation and drives EWSR1::FLI1-mediated gene regulation.
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