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    1. Developmental Biology
    2. Genetics and Genomics

    Coordinated Tbx3/Tbx5 transcriptional control of the adult ventricular conduction system

    Ozanna Burnicka-Turek, Katy A Trampel ... Ivan P Moskowitz
    Coordinated removal of Tbx3 and Tbx5 function alters the molecular features of the fast ventricular cardiac conduction system toward non-conduction working myocardium, illuminating transcriptional control of cardiac conduction system patterning.
    1. Developmental Biology

    Contraction-induced endocardial id2b plays a dual role in regulating myocardial contractility and valve formation

    Shuo Chen, Jinxiu Liang ... Peidong Han
    Endocardial id2b integrates biomechanical cues to orchestrate valve formation and myocardial maturation during cardiac development.
    1. Cell Biology

    Rho-ROCK liberates sequestered claudin for rapid de novo tight junction formation

    Yuma Cho, Akari Taniguchi ... Junichi Ikenouchi
    The Rho-ROCK–matriptase signaling axis promotes claudin release from EpCAM/TROP2 complexes, enabling tight junction reassembly during epithelial remodeling to preserve barrier integrity.
    1. Neuroscience

    The NIH BRAIN Initiative’s impacts in systems and computational neuroscience and team-scale research 2014–2023

    Farah Bader, Clayton Bingham ... James Gnadt
    The BRAIN Circuits Program of the NIH BRAIN Initiative has impacted how fundamental discovery in integrative systems neuroscience is investigated, commensurate with the complexity to address neurobehavioral and neurological dysfunctions.
    1. Neuroscience

    Social rank-order stability of mice revealed by a novel food competition paradigm in combination with available space competition paradigms

    Meiqiu Liu, Yue Chen, Rongqing Chen
    Social status of mice in an established colony is stably expressed in several types of competition paradigms, including food and space competitions.
    1. Developmental Biology
    2. Neuroscience

    Premature vision drives aberrant development of response properties in primary visual cortex

    Sophie V Griswold, Stephen D Van Hooser
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Neuroscience

    Formation of Task Representations and Replay in Mouse Medial Prefrontal Cortex

    Hamed Shabani, Hannah Muysers ... Christian Leibold
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Developmental Biology

    Multiple pathways prevent bi-parental mitochondria transmission in C. elegans

    Valentine Melin, Justine Cailloce ... Vincent Galy
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Genetics and Genomics
    2. Computational and Systems Biology

    JAX Animal Behavior System (JABS): A genetics informed, end-to-end advanced behavioral phenotyping platform for the laboratory mouse

    Anshul Choudhary, Brian Q Geuther ... Vivek Kumar
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    • Incomplete
    1. Neuroscience

    Identification of novel human microcephaly-linked protein Mtss2 that mediates cortical progenitor cell division and corticogenesis through Nedd9-RhoA

    Aurelie Carabalona, Henna Kallo ... Claudio Rivera
    ABBA ensures proper cortical development by regulating radial glial division through RhoA activity at the cleavage furrow, and its mutation results in developmental abnormalities linked to microcephaly.
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