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    1. Structural Biology and Molecular Biophysics

    Ω-Loop mutations control dynamics of the active site by modulating the hydrogen-bonding network in PDC-3 β-lactamase

    Shuang Chen, Andrew R Mack ... Shozeb Haider
    Clinically relevant Ω-loop mutations in PDC-3 reshape active-site dynamics to enhance β-lactamase activity, providing mechanistic insights that can guide the rational design of inhibitors.
    1. Computational and Systems Biology
    2. Developmental Biology

    Anti-resonance in developmental signaling regulates cell fate decisions

    Samuel J Rosen, Olivier Witteveen ... Maxwell Z Wilson
    Human cells decode dynamics Wnt signals using an anti-resonant filter that suppresses intermediate-frequency inputs and is capable of redirecting developmental fate outcomes, including germ-layer specification.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Efficient transduction of pancreas tissue slices with genetically encoded calcium integrators

    Charles S Lazimi, Austin E Stis ... Edward A Phelps
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Developmental Biology

    Permissive and instructive Hox codes govern limb positioning

    Yajun Wang, Maik Hintze ... Ruijin Huang
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Incomplete
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Effects of residue substitutions on the cellular abundance of proteins

    Thea K Schulze, Kresten Lindorff-Larsen
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Structural Biology and Molecular Biophysics

    Active regulation of the epidermal growth factor receptor by the membrane bilayer

    Shwetha Srinivasan, Xingcheng Lin ... Gabriela S Schlau-Cohen
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
    1. Cell Biology
    2. Developmental Biology

    Bruce suppresses autophagy-regulated caspase activity and wing tissue growth in Drosophila

    Natsuki Shinoda, Yutaro Hama ... Masayuki Miura
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Evolutionary Biology

    Rapid evolution of fine-scale recombination during domestication: a perspective from population genomics

    Zheng-Xi Liu, Ming Li ... Ming-Shan Wang
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    • Inadequate
    1. Neuroscience

    Modeling and simulation of neocortical micro- and mesocircuitry (Part II, Physiology and experimentation)

    James B Isbister, András Ecker ... Michael W Reimann
    A general and open multiscale cortical model is presented which can be used by the community to study neural coding, spike sorting, plasticity, optogenetic and extracellular stimulation, local field potential, and electroencephalography.
    1. Neuroscience

    Modeling and simulation of neocortical micro- and mesocircuitry (Part I, anatomy)

    Michael W Reimann, Sirio Bolaños-Puchet ... Srikanth Ramaswamy
    A morphologically detailed model of brain region anatomy serves as the foundation for biophysically detailed simulations and provides insights into local and inter-regional connectivity.
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