Browse our latest research

Page 50 of 1,695
    1. Developmental Biology

    Spinal neural tube formation and tail development in human embryos

    Chloe Santos, Abigail R Marshall ... Andrew J Copp
    Analysis of 108 human embryos aged 3–7 weeks reveals modes of primary and secondary neurulation, regulation of body elongation, somite formation rate, and common occurrence of a split neural tube.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    PfMORC protein regulates chromatin accessibility and transcriptional repression in the human malaria parasite, Plasmodium falciparum

    Zeinab M Chahine, Mohit Gupta ... Karine G Le Roch
    The PfMORC protein is proven to play a crucial role in chromatin structure, gene regulation and heterochromatin stability, categorizing PfMORC as a strong potential candidate for novel therapeutic interventions.
    1. Biochemistry and Chemical Biology

    Minimal twister sister-like self-cleaving ribozymes in the human genome revealed by deep mutational scanning

    Zhe Zhang, Xu Hong ... Jian Zhan
    The minimal twister sister (TS)-like self-cleaving ribozymes, revealed by deep mutational scanning, represent some of the very few human/primate ribozymes.
    1. Computational and Systems Biology
    2. Neuroscience

    Modeled grid cells aligned by a flexible attractor

    Sabrina Benas, Ximena Fernandez, Emilio Kropff
    Continuous attractor networks can constrain population activity to manifolds with topology radically different from that of the network architecture.
    1. Neuroscience

    When abstract becomes concrete, naturalistic encoding of concepts in the brain

    Viktor Nikolaus Kewenig, Gabriella Vigliocco, Jeremy I Skipper
    A novel deep-learning-based computational method using object recognition to quantify visual context in naturalistic, multimodal stimuli demonstrates that a concept's perceived abstractness or concreteness dynamically depends on its visual context.
    1. Immunology and Inflammation

    Distinct T-cell receptor (TCR) gene segment usage and MHC-restriction between foetal and adult thymus

    Jasmine Rowell, Ching-In Lau ... Tessa Crompton
    The foetal thymic T-cell receptor (TCR) repertoire is distinct from adult, and it is less governed by MHC-restriction, more closely encoded by genomic sequence with distinct gene-segment usage including 3’TRAV to 5’TRAJ.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    A conserved cell-pole determinant organizes proper polar flagellum formation

    Erick E Arroyo-Pérez, John C Hook ... Simon Ringgaard
    FipA is a novel component required for bacteria that rely on FlhF/FlhG to properly localize their flagella to the cell pole.
    1. Cell Biology
    2. Neuroscience

    Endogenous hydrogen peroxide positively regulates secretion of a gut-derived peptide in neuroendocrine potentiation of the oxidative stress response in Caenorhabditis elegans

    Qi Jia, Drew Young ... Derek Sieburth
    Stress-regulated secretion of an intestinal peptide positively regulates the antioxidant response by promoting neuropeptide release from the nervous system, defining a gut-to-brain-to-gut endocrine axis in the oxidative stress response.
    1. Biochemistry and Chemical Biology
    2. Medicine

    Synthesis and biological assessment of chalcone and pyrazoline derivatives as novel inhibitor for ELF3-MED23 interaction

    Soo-Yeon Hwang, Kyung-Hwa Jeon ... Youngjoo Kwon
    Structure-based designed chalcone and pyrazoline derivatives inhibited the ELF3-MED23 protein-protein interaction, leading to HER2 downregulation and retardation of tumor growth in HER2-positive gastric cancer.
    1. Neuroscience

    Parallel mechanisms signal a hierarchy of sequence structure violations in the auditory cortex

    Sara Jamali, Sophie Bagur ... Brice Bathellier
    Responses to local and global violations in sound sequences are prediction errors and not simply the consequence of stimulus-specific adaptation.