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    1. Neuroscience

    AgRP1 modulates breeding season-dependent feeding behavior in female medaka

    Yurika Tagui, Shingo Takeda ... Chie Umatani
    AgRP1, a feeding-related peptide in the brain, facilitates feeding behavior of female medaka in the breeding season, which is important for reproductive success.
    1. Microbiology and Infectious Disease

    A bacterial regulatory uORF senses multiple classes of ribosome-targeting antibiotics

    Gabriele Baniulyte, Joseph T Wade
    An upstream open-reading frame in Escherichia coli regulates expression of the downstream genes in response to diverse translation stresses.
    1. Microbiology and Infectious Disease

    Primosomal protein PriC rescues replication initiation stress by bypassing the DnaA-DnaB interaction step for DnaB helicase loading at oriC

    Ryusei Yoshida, Kazuma Korogi ... Tsutomu Katayama
    PriC provides a bypass mechanism for compromised helicase loading at the origin of the Escherichia coli chromosome, which ensures the robustness of the chromosome replication initiation.
    1. Cell Biology
    2. Developmental Biology

    Mutations that prevent phosphorylation of the BMP4 prodomain impair proteolytic maturation of homodimers leading to lethality in mice

    Hyung-Seok Kim, Mary L Sanchez ... Jan L Christian
    Phosphorylation of the BMP4 prodomain is required for proteolytic activation of BMP4 homodimers, but not BMP4/7 heterodimers.
    1. Cancer Biology

    Inhibition of p38-MK2 pathway enhances the efficacy of microtubule inhibitors in breast cancer cells

    Yu-Chia Chen, Mamoru Takada ... Aussie Suzuki
    Inhibiting the p38 MAPK-MK2 signaling pathway significantly boosts the efficacy of microtubule-targeting agents specifically in breast cancer cells, highlighting a potential new therapeutic strategy for improved cancer treatment.
    1. Cell Biology

    Force transmission through the inner kinetochore is enhanced by centromeric DNA sequences

    Elise Miedlar, Grace E Hamilton ... Trisha N Davis
    Biochemical reconstitution and laser trapping show that centromeric DNA sequences are important for the transmission of microtubule-based forces to chromosomes.
    1. Chromosomes and Gene Expression

    Genome organization by SATB1 binding to base-unpairing regions (BURs) provides a scaffold for SATB1-regulated gene expression

    Yoshinori Kohwi, Xianrong Wong ... Terumi Kohwi-Shigematsu
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Immunology and Inflammation

    Temperature-based MHC class-I multimer peptide exchange for human HLA-A, B and C

    Cilia R Pothast, Ian Derksen ... Ferenc A Scheeren
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Developmental Biology

    Integrated transcriptomic analysis of human induced pluripotent stem cell-derived osteogenic differentiation reveals a regulatory role of KLF16

    Ying Ru, Meng Ma ... Meng Wu
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Neuroscience

    Vascular endothelial-specific loss of TGF-beta signaling as a model for choroidal neovascularization and central nervous system vascular inflammation

    Yanshu Wang, Amir Rattner ... Jeremy Nathans
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
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