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    1. Neuroscience

    Restoration of locomotor function following stimulation of the A13 region in Parkinson’s mouse models

    Linda H Kim, Adam P Lognon ... Patrick J Whelan
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Developmental Biology

    Site-specific DNA demethylation during spermatogenesis presets the sites of nucleosome retention in mouse sperm

    So Maezawa, Masashi Yukawa ... Satoshi H Namekawa
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    Top-down feedback matters: Functional impact of brainlike connectivity motifs on audiovisual integration

    Mashbayar Tugsbayar, Mingze Li ... Blake Richards
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Neuroscience

    Cingulate cortex shapes early postnatal development of social vocalizations

    Gurueswar Nagarajan, Denis Matrov ... Yogita Chudasama
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Cancer Biology
    2. Cell Biology

    Cytosolic and endoplasmic reticulum chaperones inhibit wt-p53 to increase cancer cells' survival by refluxing ER-proteins to the cytosol

    Salam Dabsan, Gali Zur ... Aeid Igbaria
    Identifying the regulators of a non-genetic mechanism (ERCYS) that is constitutively activated in cancer cells to provide pro-survival properties.
    1. Neuroscience

    Repeated activation of preoptic area recipient neurons in posterior paraventricular nucleus mediates chronic heat-induced negative emotional valence and hyperarousal states

    Zhiping Cao, Wing-Ho Yung, Ya Ke
    A neural circuit mechanism explains how chronic extreme heat exposure affects emotions in the mouse model.
    1. Developmental Biology

    Numb provides a fail-safe mechanism for intestinal stem cell self-renewal in adult Drosophila midgut

    Mengjie Li, Aiguo Tian, Jin Jiang
    The asymmetrically segregated Notch pathway inhibitor Numb is essential for intestinal stem cell self-renewal in adult Drosophila midguts when the stem cell niche signaling is compromised.
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    High-resolution deep mutational scanning of the melanocortin-4 receptor enables target characterization for drug discovery

    Conor J Howard, Nathan S Abell ... Nathan B Lubock
    Mapping the functional landscape of >6600 MC4R variants via deep mutational scanning reveals novel determinants of biased signaling and ligand interactions that inform targeted obesity therapeutics.
    1. Microbiology and Infectious Disease

    Screening Envelope Genes Across Primate Genomes Reveals Evolution and Diversity Patterns of Endogenous Retroviruses

    Saili Chabukswar, Nicole Grandi ... Enzo Tramontano
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Biochemistry and Chemical Biology

    Isolating Small Extracellular Vesicles from Small Volumes of Blood Plasma using size exclusion chromatography and density gradient ultracentrifugation: A Comparative Study

    Fang Kong, Megha Upadya ... Ming Dao
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
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