Browse our latest research

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    1. Epidemiology and Global Health

    Measuring changes in Plasmodium falciparum census population size in response to sequential malaria control interventions

    Kathryn E Tiedje, Qi Zhan ... Karen P Day
    Despite major perturbations from sequential interventions, the Plasmodium falciparum population remained very large and retained the var population genetic characteristics of a high-transmission system.
    1. Neuroscience

    Neuronal migration depends on blood flow in the adult mammalian brain

    Takashi Ogino, Akari Saito ... Kazunobu Sawamoto
    Blood flow enhances neuronal migration in the adult brain via ghrelin signaling.
    1. Computational and Systems Biology
    2. Medicine

    Critique of impure reason: Unveiling the reasoning behaviour of medical large language models

    Shamus Zi Yang Sim, Tyrone Chen
    A survey of reasoning behaviour in medical large language models uncovers emerging trends, highlights open challenges, and introduces theoretical frameworks that enhance reasoning behaviour transparency, ultimately fostering greater trust among clinicians, developers, and patients in their deployment.
    1. Neuroscience

    Nocebo effects are stronger and more persistent than placebo effects in healthy individuals

    Angelika Kunkel, Katharina Schmidt ... Ulrike Bingel
    In healthy volunteers, negative expectations exert stronger and longer-lasting effects on pain than positive expectations, consistent with a better-safe-than-sorry account of placebo and nocebo effects.
    1. Cell Biology

    The Rab7-Epg5 and Rab39-ema modules cooperatively position autophagosomes for efficient lysosomal fusions

    Attila Boda, Villő Balázs ... Péter Lőrincz
    An RNAi based genetic screen and subsequent analyses reveal how dyneins and small GTPases coordinate autophagosome positioning at the ncMTOC in fat cells, advancing understanding of autophagic vesicle transport.
    1. Neuroscience

    Newly trained navigation and verbal memory skills in humans elicit changes in task-related networks but not brain structure

    Li Zheng, Zachary Boogaart ... Steven M Weisberg
    Learning new navigation or memory skills engages flexible brain network dynamics without altering gray matter, white matter, or hippocampal structure.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Cell membrane glycan contents are biochemical factors that constitute a kinetic barrier to viral particle uptake in a protein-nonspecific manner

    Yoshihisa Kaizuka, Rika Machida
    Intermolecular steric repulsion generated by glycans on the cell membrane inhibits viral infection by preventing the formation of a virus-cell interface, regardless of the identity of molecules for glycan modification.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Pleomorphic effects of three small-molecule inhibitors on transcription elongation by Mycobacterium tuberculosis RNA polymerase

    Omar Herrera-Asmat, Alexander B Tong ... Carlos Bustamante
    Optical tweezers are used to gain mechanistic insight in the mechanism of inhibition of three distinct compounds being developed as antibiotics against Mycobacterium tuberculosis.
    1. Developmental Biology
    2. Cancer Biology

    Tumors mimic the niche to inhibit neighboring stem cell differentiation

    Yang Zhang, Yuejia Wang ... Shaowei Zhao
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Structural Biology and Molecular Biophysics

    Structure of the human CTF18−RFC clamp loader bound to PCNA

    Giuseppina R Briola, Muhammad Tehseen ... Alfredo De Biasio
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    • Incomplete