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    1. Structural Biology and Molecular Biophysics

    Cryo-EM structure of the bicarbonate receptor GPR30

    Shota Kaneda, Airi Jo-Watanabe ... Osamu Nureki
    Cryo-electron microscopy structure of human G-protein-coupled receptor 30 in the presence of bicarbonate ions revealed unique extracellular pockets and critical residues for bicarbonate binding and activation.
    1. Genetics and Genomics

    Sibling chimerism among microglia in marmosets

    Ricardo CH del Rosario, Fenna M Krienen ... Steven A McCarroll
    Sibling-derived chimerism in marmosets is found only in cells of hematopoietic origin, especially microglia and macrophages in the brain, whose proportions vary widely across individuals and brain regions.
    1. Neuroscience

    Nitric oxide feedback to ciliary photoreceptor cells gates a UV avoidance circuit

    Kei Jokura, Piotr Słowiński ... Gáspár Jékely
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
    1. Immunology and Inflammation
    2. Neuroscience

    The G-protein coupled receptor GPR34 promotes the homeostatic state of microglia and restrains the disease-associated microglial response in an Alzheimer’s disease model

    Ana Geller, Min Jee Kwon ... Prabhat S Kunwar
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Quantifying microbial fitness in high-throughput experiments

    Justus Wilhelm Fink, Michael Manhart
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Convincing
    1. Cell Biology

    WNKs regulate mouse behavior and alter central nervous system glucose uptake and insulin signaling

    Ankita B Jaykumar, Derk Binns ... Melanie H Cobb
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Solid
    • Convincing
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    Nucleation-dependent propagation of Polycomb modifications emerges during the Drosophila maternal to zygotic transition

    Natalie Gonzaga-Saavedra, Eleanor A Degen ... Shelby A Blythe
    Epigenomics and quantitative imaging are used to investigate the re-establishment of histone modifications associated with the Polycomb group of epigenetic regulators during the Drosophila maternal-to-zygotic transition.
    1. Neuroscience

    Parkinson’s disease-associated PINK1 loss disrupts ensheathing glia and causes dopaminergic neuron synapse loss

    Lorenzo Ghezzi, Sabine Kuenen ... Patrik Verstreken
    Parkinson’s disease-linked Pink1 loss disrupts protective glial support, and targeting glial vesicle trafficking preserves dopaminergic synapses.
    1. Neuroscience

    Population-level temporal decoding and dynamical structure in frontostriatal circuits during decision making

    Adam B Goldring, Anandita De ... Timothy D Hanks
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Neuroscience

    Rhythmic temporal structure organizes recurrent dynamics to support sequential working memory

    Yitao Qin, Yun Yang ... Tielin Zhang
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
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