Browse our latest research

Page 505 of 1,838
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    Systematic analysis of the molecular and biophysical properties of key DNA damage response factors

    Joshua R Heyza, Mariia Mikhova ... Jens C Schmidt
    Live-cell single-molecule imaging of DNA repair factors can be used to analyze their localization to DNA lesions and dissect the hierarchy of their recruitment.
    1. Neuroscience

    Ketamine’s rapid antidepressant effects are mediated by Ca2+-permeable AMPA receptors

    Anastasiya Zaytseva, Evelina Bouckova ... Seonil Kim
    Ketamine induces the expression of Ca2+-permeable AMPA receptors to enhance synaptic glutamatergic and Ca2+ activity in neurons to cause rapid antidepressant effects.
    1. Microbiology and Infectious Disease

    Resolving the origins of secretory products and anthelmintic responses in a human parasitic nematode at single-cell resolution

    Clair R Henthorn, Paul M Airs ... Mostafa Zamanian
    A single-cell gene expression atlas in a human parasitic nematode provides new insights into the distribution of anthelmintic targets and the origins of secretory molecules with diagnostic and therapeutic potential at the host–parasite interface.
    1. Genetics and Genomics

    A genetic and linguistic analysis of the admixture histories of the islands of Cabo Verde

    Romain Laurent, Zachary A Szpiech ... Paul Verdu
    The complex histories of social relationships between enslaved and non-enslaved communities and their descendants during and after the Trans-Atlantic Slave-Trade shaped the detailed genetic and linguistic histories of admixture of the islands of Cabo Verde.
    1. Immunology and Inflammation

    Prolonged T-cell activation and long COVID symptoms independently associate with severe COVID-19 at 3 months

    Marianna Santopaolo, Michaela Gregorova ... Laura Rivino
    Prolonged CD4+ and CD8+ T-cell activation and long COVID symptoms at 3 months post hospitlization independently associate with severe COVID-19, and ongoing T-cell activation does not affect the generation and maintenance of memory T-cell and antibody responses to SARS-CoV-2.
    1. Microbiology and Infectious Disease

    Extensive remodelling of the cell wall during the development of Staphylococcus aureus bacteraemia

    Edward JA Douglas, Nathanael Palk ... Ruth C Massey
    The transition of Staphylococcus aureus from commensalism to invasive disease, bacteraemia, is a complex balancing act offsetting offensive and defensive virulence strategies involving the Tca cell wall stress stimulon locus.
    1. Neuroscience

    Aerobic exercise reverses aging-induced depth-dependent decline in cerebral microcirculation

    Paul Shin, Qi Pian ... Sava Sakadžić
    Cerebral subcortical microcirculation is more vulnerable to aging-induced changes and more responsive to exercise than cortical microcirculation.
    1. Genetics and Genomics

    High-throughput library transgenesis in Caenorhabditis elegans via Transgenic Arrays Resulting in Diversity of Integrated Sequences (TARDIS)

    Zachary C Stevenson, Megan J Moerdyk-Schauwecker ... Patrick C Phillips
    TARDIS enables efficient and diverse transgenesis in Caenorhabditis elegans by integrating synthetic DNA libraries into engineered genomic sites, rivaling the scale of transformation previously only possible in microbes.
    1. Microbiology and Infectious Disease

    A framework for community curation of interspecies interactions literature

    Alayne Cuzick, James Seager ... Kim E Hammond-Kosack
    A framework has been devised that enables global participation in the curation of publications on any topic involving two or more living organisms, ranging from microscopic to larger sizes, in their natural or artificial environments or ecosystems.
    1. Microbiology and Infectious Disease

    Cell detoxification of secondary metabolites by P4-ATPase-mediated vesicle transport

    Yujie Li, Hui Ren ... Yan Pei
    P4-ATPase BbCrpa detoxifies secondary metabolites via a unique vesicle-mediated transport pathway that targets the compounds into vacuoles.