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Selective involvement of Arp2/3 complex subunit isoforms ARPC5 or ARPC5L governs the distinct actin polymerization events in the nucleus or cytoplasm of CD4 T cells that are triggerd by T cell activation or DNA replication stress.

The small macrophage-secreted protein RELMα is a sex-specific protein that protects against diet-induced obesity through regulating the macrophage–eosinophil innate immune axis in the adipose tissue.

Major neuron classes are activated when the fly walks, whether it chooses or is forced to do so.

The health benefits of caloric restriction, including decreasing body fat and blood glucose, differ between males and females and this difference depends on the age at which caloric restriction begins.

Nearly half of the transcriptome is altered when endothelial cells transition in vitro, expression patterns for some genes are regained by exposing cells to shear stress and others through exposure to smooth muscle cells.

Intracellular NASPM, unlike the widely used spermine, fully blocks outward currents through calcium-permeable AMPA-type glutamate receptors, enabling an improved functional readout for this physiologically important receptor subtype in neurons.

Preclinical multilaboratory studies are a robust method to assess promising interventions.

Elevated growth rates and increased size-at-age leads to a larger population size structure, despite higher mortality and a younger population after three decades of exposure to 5–10°C higher temperatures in a large-scale natural climate change experiment.

Touch-mediated social interactions in human females elicited endogenous oxytocin and brain responses in a covariant manner, and these changes were modulated by the familiarity of the person delivering touch as well as the recent history of social interaction.

The absence of generally assumed strong correlations between striatal dopamine synthesis capacity and simple indices of working memory capacity, trait impulsivity, and spontaneous eye-blink rate warrants caution for using these traits as proxy measures to replace direct striatal dopamine assessments.