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As the first to track clonal evolution from precancerous to metastatic lesions in gallbladder cancer patients, spatial and temporal analyses reveal how subclonal diversity in precancerous stage changes toward the metastasis, which help early detection and effective treatment of cancer.

The functional link between glycolytic flux, cell signalling and mesoderm patterning is investigated in mouse embryo.

Unbiased single-cell RNAseq data analysis combined with mouse genetic approaches reveal that TGF-β signaling and perimysial-specific regulators may cooperatively define perimysial-to-myogenic signals in regulating pharyngeal myogenesis.

Genetic analysis of senataxin and RNase H2-deficient mice reveals that genome stability during class switch recombination and antibody generation can be uncoupled, suggesting a role for R loop metabolism dysfunction in lymphomagenesis in patients without immune deficiency.

Pharmacological and genetic blockade of β1-AR-Gαs signaling prolongs the cardiac regenerative window in juvenile mouse by activating YAP.

Weakly migratory cancer cells facilitate their own escape from the primary tumor by releasing microvesicles that activate fibroblasts to remodel matrix and facilitate cancer cell metastasis.

Biochemical and cellular analyses reveal the mechanism by which EROS regulates NOX2 and P2X7 abundance in mouse and human.

Constitutive activation of an innate immunity response in mouse brain causes degeneration of dopaminergic neurons, suggesting novel targets for potentially neuroprotective strategies.

Environmental DNA from highly standardized leaf sample time series suggests no localized species losses, but biotic turnover and homogenization, as main drivers of forest insect decline.

Computed tomography data reveal large and adult-looking inner ears in very young individuals of the long-necked dinosaur Europasaurus holgeri suggesting precociality in this dwarfed island dweller from the Late Jurassic of Germany.