The central immune modulator interferon-gamma downregulates the proto-oncogene c-Myc to shut down host cell metabolism and interfere with infection of epithelial cells by obligate intracellular pathogenic Chlamydia trachomatis.
Elizabeth M Sefton, Mirialys Gallardo ... Gabrielle Kardon
HGF derived from fibroblasts is critical for complete muscularization of the mammalian diaphragm, and loss-of-function experiments reveal that partial muscularization of the diaphragm is not sufficient to cause congenital diaphragmatic hernias.
Sophie R Sichel, Benjamin P Bratton, Nina R Salama
The helical cell shape of Helicobacter pylori depends on the polymerizing cytoskeletal protein CcmA’s recruitment to the cell envelope by Csd5 and CcmA’s indirect stabilization of a periplasmic cell wall hydrolase via interactions with the transmembrane protein Csd7.
Anadika R Prasad, Inês Lago-Baldaia ... Vilaiwan M Fernandes
Extrinsic signals establish an invariant and stereotyped pattern of neuronal differentiation and programmed cell death in the Drosophila visual system.
Gina M LoMastro, Chelsea G Drown ... Andrew Jon Holland
Genetically engineered mouse models show that PLK4 protein and kinase activity are essential for multiciliogenesis, demonstrating that the early steps of centriole assembly are conserved between cycling and multiciliated cells.
Shawn P Shortill, Mia S Frier ... Elizabeth Conibear
The yeast VARP homolog forms a new sorting nexin complex that promotes its own membrane recruitment through GEF activity and regulates the distribution of endosomal proteins.
Brandt Warecki, Simon William Abraham Titen ... William Sullivan
Differentiation of mitotic errors occurring during late embryonic development from the well-characterized first division defects provides new insight into the mechanisms of Wolbachia-induced cytoplasmic incompatibility.
Under systemic iron overload, translational derepression of ferroportin mRNA via the IRE/IRP system antagonizes hepcidin-mediated ferroportin degradation to coordinately control serum iron.
Human colonic organoid monolayers self organize into regularly spaced stem and differentiated cell compartments, which are maintained by waves of ERK activity originating from extruded/dying cells.
