The sulfonate analog of glycine is very efficacious in activating glycine channels and causes conformational changes in this pentameric ligand-gated channel that are similar to those produced by glycine itself.
A new tool enables measuring feeding and locomotion simultaneously which will enable insights into environmental, developmental, neuronal, and genetic factors underlying behavioral regulation.
The flavoprotein NrdI in class Ib ribonucleotide reductase controls superoxide generation and metal site oxidation by tuning the redox properties of its flavin cofactor via steric strain induced by the formation of the R2b–NrdI protein complex.
Hedgehog leads to Smoothened accumulation by favoring its recycling and high Hedgehog levels promote a basolateral enrichment of Smoothened via its phosphorylation by the protein kinase Fused.
Arc-shaped PFO oligomers consisting of at least four subunits can insert into the membrane in a kinetically controlled process opening a transmembrane pore, whereby post-insertion growth may ultimately lead to formation of a complete ring.
Single-cell RNA sequencing reveals HLJ1 as a novel immunomodulator for multicellular pathway of macrophages and NK cells, contributing to organ injury and sepsis death through amplified IL-12/IFN-γ axis.
Category-selective intracerebral neurophysiological activity in low- and high-frequency bands show unprecedented corresponding spatial, functional, and timing properties in the human brain.
A computational model of decision making suggests that the dorsolateral prefrontal cortex's role in self-control is more associated with evidence accumulation processes than with inhibition or modulation of value.
