Under fluid shear, living cells deform elliptically, align in flow direction, and rotate, from which their frequency-dependent viscoelastic properties can be inferred.
In a mouse model of psychiatric illness, the neuronal network of the medial prefrontal cortex is characterized by reduced activity levels of interneurons, impaired gamma oscillations, and altered activation of cell assemblies.
Zicheng Hu, Kattria van der Ploeg ... Prasanna Jagannathan
Immune markers measured at the early stage of COVID-19 infection are associated with various clinical outcomes and can be used to predict disease progression, T cell memory, viral shedding, and the antibody response of the COVID-19 patients.
Genetic lineage tracing reveals the cardiopharyngeal mesoderm as a cellular origin of craniofacial and cardiac lymphatic vessels, which most often affected in lymphatic malformation patients.
The analysis of mass-spectrometry data for all possible open reading frames reveals protein evidence for evolutionarily young, unannotated proteins with distinct characters.
Single-cell tracking and cell-fate simulation suggest that low levels of p53 suppress aneuploid cell formation in unstressed cells and also reveal the dual fate of cells lacking p53 in the presence of p53-proficient cells.
Mammalian cells were engineered to synthesize valine, a metabolic capacity that had been lost from the lineage of higher eukaryotes for >500 million years.
Histone H3 can translocate to the nucleus as a monomer through a pathway governed by importin-5 and transfers to the histone chaperone NASP, having implications in the folding of H3-H4 dimers and, therefore, the kinetics of genome packaging during replication.
Andrea Navas-Olive, Rodrigo Amaducci ... Liset M de la Prida
A new method is described to identify sharp-wave ripples from the rodent hippocampus with deep learning techniques, which may help to identify and characterize previously undetected physiological events.
