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Comprehensive multi-neuron fluorescence imaging in C. elegans reveals age-associated changes in neuronal activity that include a breakdown of system-wide organization, changes in neuronal frequency dynamics, and a disruption of the balance between excitatory and inhibitory signaling.

Bone marrow adipocyte lipolysis is required for maintaining bone mass under conditions of energy deficiency and is necessary for myelopoiesis following caloric restriction and irradiation.

A new mathematical method has been developed, implemented and validated for the analysis of time-lapse confocal laser scanning microscopy images to characterize the swimming behavior of bacterial swimmers moving in the exogenous matrix of pathogenic biofilms.

Analyses of spindle genes with missense changes in modern humans reveal evidence for positive selection since the split with archaic humans and show that modern humans interacted with Neandertals more than once in the past 200,000 years.

Both human and microbe cell-free RNA features in plasma could distinguish tumors of different primary locations.

A large-scale analysis of Staphylococcus aureus within-host evolution based on a comprehensive catalogue of bacterial genetic variation reveals an excess of genome degradation signatures in infecting strains and new genetic loci of clinically relevant adaptation.

The circadian clock gates sleep drive by modulating sleep homeostat neurons.

Pathological TNF-α-producing B cells are involved in the pathological process of polycystic ovary syndrome, and metformin inhibits mTOR phosphorylation, affects metabolic reprogramming, and further inhibits TNF-α expression in pathological B cells.

Distinct surfaces of an interbacterial competition cell wall toxin mediate interactions with different cellular binding partners, resulting in an inherent evolutionary trade-off across the toxin superfamily.

A novel strategy to create genetic mosaics in zebrafish for cell type-specific analysis of gene function that can be applied to any gene of interest.