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A method to reduce the noise present in field experiments by accounting for heterogeneity in field soils.

Cranial endocasts of fossil and extant lungfish, analysed via tomography and novel principle component analyses designed for use with missing data, show that lungfish forebrain and inner ear regions show the most variation in brain shape evolution through time.

Among three new models for KCNMA1 channelopathy, the most severe gain-of-function variant (Kcnma1^N999S/WT) displays a particular type of immobilizing paroxysmal dyskinesia observed in patients, including amphetamine responsiveness.

Auxin-inducible degradation of CRISPR-tagged endogenous proteins in mice reveals cell-type-specific dependence on the mitotic chromosome condensation proteins.

By measuring the impacts of thousands of mutations on potassium channel trafficking and function, we illuminate the molecular basis of folding, structure–function relationships, and how these are altered in disease.

A mitochondrial membrane-bound protein ATAD1 uses conserved structural elements to remove mislocalized membrane proteins from the outer mitochondrial membrane, achieving proper cell organization.

Intervention of CHI3L1 using anti-CHI3L1 monoclonal antibody or chitinase inhibitor kasugamycin blocks epithelial infection of various SARS-CoV2 variants, suggesting that CHI3L1 is a universal and effective therapeutic target of COVID-19 infection, including recent omicron variants.

Trigeminal nerve deficits observed in familial dysautonomia, which arises from mutations in ELP1, are due to loss of neural crest-derived TrkA nociceptors, while placode-derived TrkB and TrkC neurons are spared.

Comprehensive multi-neuron fluorescence imaging in C. elegans reveals age-associated changes in neuronal activity that include a breakdown of system-wide organization, changes in neuronal frequency dynamics, and a disruption of the balance between excitatory and inhibitory signaling.

Bone marrow adipocyte lipolysis is required for maintaining bone mass under conditions of energy deficiency and is necessary for myelopoiesis following caloric restriction and irradiation.