Artem Mikelov, Evgeniia I Alekseeva ... Ivan V Zvyagin
High degree of clonal persistence and excess of inter-individual convergence are observed in human memory B cell repertoires, along with signatures of both negative and positive selection in most abundant clonal lineages.
The recurring application of computational modelling combined with wet lab experiments identify and predict central regulatory parameters and factors for early cell physiological reactions linked to differential brassinosteroid-modified elongation growth in the root tip of Arabidopsis thaliana.
In the cochlea, repressor element 1-silencing transcription factor (REST) regulates the expression levels of Kv7.4 and alterations of REST functions result in progressive hearing loss.
LPS pre-exposure is tissue protective during a subsequent lethal E. coli peritonitis by long-term modulation the bone marrow B-cell and neutrophil pool which affects neutrophil tissue damaging properties and therapeutic activation of Cxcr4 promotes tissue damage control during sepsis.
James N McGregor, Abigail L Grassler ... Samuel J Sober
A novel, non-auditory learning paradigm reveals that songbirds can modify their vocal output based on somatosensory signals and that a common set of brain pathways underlies both this form of vocal learning and auditory-guided vocal learning.
Predicted gene regulatory networks active in planarians adult stem cells provide testable hypotheses about the control of pluripotency and differentiation in animals.
A new method for analyzing continuous psychophysics experiments estimates not only perceptual uncertainty from tracking tasks but also action variability, intrinsic costs, and subjective internal models.
A new binding mode between Rabphilin 3A and SNAP-25 enables efficient SNARE complex assembly via inducing a conformation change in SNAP-25 SNARE motif.
Human neuroimaging with time-evolving network analysis reveals dynamic interactions among multiple functional brain networks in response to sustained pain.
