Browse our latest research

Page 618 of 1,810
    1. Neuroscience

    Insulin sensitivity in mesolimbic pathways predicts and improves with weight loss in older dieters

    Lena J Tiedemann, Sebastian M Meyhöfer ... Stefanie Brassen
    Insulinergic neuromodulation of hedonic food processing predicts future weight management and improves with weight loss in older overweight dieters.
    1. Neuroscience

    Mixed synapses reconcile violations of the size principle in zebrafish spinal cord

    Evdokia Menelaou, Sandeep Kishore, David L McLean
    In the zebrafish spinal cord, mixed synapses contribute to neuronal connectivity and resting excitability, which helps explain violations of the well-known 'size principle' of recruitment.
    1. Neuroscience

    Quantitative MRI reveals differences in striatal myelin in children with DLD

    Saloni Krishnan, Gabriel J Cler ... Kate E Watkins
    A new quantitative MRI protocol reveals reduced myelin in the striatum in children with developmental language disorder, shedding light on the brain basis of this disorder.
    1. Ecology

    Bumblebees retrieve only the ordinal ranking of foraging options when comparing memories obtained in distinct settings

    Cwyn Solvi, Yonghe Zhou ... Fei Peng
    Unlike humans and starlings which use memories of both absolute and relative information to decide between options in novel contexts, bumblebees rely only on the remembered ordinal ranking of options.
    1. Epidemiology and Global Health

    The effect of calcium supplementation in people under 35 years old: A systematic review and meta-analysis of randomized controlled trials

    Yupeng Liu, Siyu Le ... Shuran Wang
    A systematic review and meta-analysis show that calcium supplementation significantly improves bone mass, implying that preventive calcium supplementation in young people (age ≤35 years) may be a shift in the window of intervention for osteoporosis.
    1. Epidemiology and Global Health

    Trends in female-selective abortion among Asian diasporas in the United States, United Kingdom, Canada and Australia

    Catherine Meh, Prabhat Jha
    While selective abortion of female fetuses is documented within China and India, it is also significant among Asian diaspora in Canada, US, UK and Australia, particularly among Indian diaspora for second or third births following earlier girl birth(s).
    1. Cancer Biology

    Arbidol inhibits human esophageal squamous cell carcinoma growth in vitro and in vivo through suppressing ataxia telangiectasia and Rad3-related protein kinase

    Ning Yang, Xuebo Lu ... Kangdong Liu
    Arbidol is a ATR inhibitor to reduce the phosphorylation and activation of MCM2 at Ser108, and innhibits the cell proliferation of ESCC in vitro and in vivo through the DNA replication and cell cycle pathway.
    1. Immunology and Inflammation
    2. Medicine

    Neutrophil-mediated fibroblast-tumor cell il-6/stat-3 signaling underlies the association between neutrophil-to-lymphocyte ratio dynamics and chemotherapy response in localized pancreatic cancer: A hybrid clinical-preclinical study

    Iago de Castro Silva, Anna Bianchi ... Jashodeep Datta
    A neutrophil-CAF-tumor cell IL-1β/IL-6/STAT-3 signaling axis in the pancreatic tumor microenvironment underlies the association between neutrophil-to-lymphocyte ratio dynamics and pathologic response in patients with pancreatic ductal adenocarcinoma undergoing neoadjuvant therapy.
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    Fip1 is a multivalent interaction scaffold for processing factors in human mRNA 3′ end biogenesis

    Lena Maria Muckenfuss, Anabel Carmen Migenda Herranz ... Martin Jinek
    Molecular details of the interactions of human Fip1 with CPSF30 and CstF77 unravel key aspects of mRNA polyadenylation and its regulation.
    1. Immunology and Inflammation
    2. Medicine

    Bone marrow adipocytes drive the development of tissue invasive Ly6Chigh monocytes during obesity

    Parastoo Boroumand, David C Prescott ... Amira Klip
    Diet-induced obesity in mice led to a duration of diet-dependent bone marrow adipocyte whitening, which drove monocyte expansion and skewing towards a tissue-invasive phenotype, likely contributing to ensuing tissue infiltration that accompanies obesity and diabetes.