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Mindbomb1 acts independently of it well-known role in Notch signalling to control the endocytic internalization of the Wnt co-receptor Ryk and thereby modulate the activity of the Planar Cell Polarity pathway that governs morphogenetic movements during embryonic development.

The upregulation of TLN1 contributes to the metastasis of triple-negative breast cancer (TNBC), and a small-molecule C67399 was screened for blocking TLN1 and integrin β1 may hold promise for the treatment of TNBC.

Shank promotes functional coupling between CaV1 calcium channels and BK potassium channels.

Responses to odour mixtures are more discriminable in awake, behaving mice due to a combination of dampened responses keeping responses in the linear range and pattern decorrelation, with these two mechanisms operating on different timescales.

All steps of a viroid-like replication cycle can be catalyzed by RNA alone.

The higher order thalamus encodes and influences correct action during learning and performance in a sensory-based goal-directed behavior.

Through associative learning, environmental context can come to exert control over the endogenous opioid system such that it is recruited as a conditioned compensatory response to ongoing painful stimuli in both male and female mice, or in anticipation of a painful stimulus in females.

Functional neuroimaging in the human brain reveals the neurocognitive mechanisms that underpin the experience of mind-wandering during reading, explaining why comprehension is impaired.

TRACC (Transcriptional Readout Activated by Cell-cell Contacts) is an engineered molecular tool that detects and records cell-cell contacts in mammalian systems.

Flow stimulates PC-1/PC-2 clusters in the plasma membrane of endothelial cells, leading to Ca²⁺ influx, NOS, SK channel, and IK channel activation, vasodilation, and a reduction in blood pressure.