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Timing of neural precursor cells division controls the order of development of sensory neurons, which in turn determines their axon terminal pattern and ultimately fly behaviour.

A comprehensive molecular description of the cellular transition into replicative senescence provides evidence of metabolic, epigenetic, and regulatory rewiring that links senescence with wound healing and fibrosis.

Quantitative proteomics reveals the diversity and heterogeneity of nuclear proteomes in mammalian organs and identifies the molecular features of ageing.

Ribosomal protein mutations, mutations that affect ribosomal RNA synthesis, or function of the mature ribosome, trigger a transcriptional response mediated by Xrp1 expression which reduces cellular translation via eIF2-alpha phosphorylation and renders cells liable to competition with wild-type neighbors.

Irradiation of normal human fibroblasts and mice in conditions mimicking standard external X-ray radiotherapy protocols highlights that noncancerous cells surrounding the planning target volume accumulate DNA single-strand breaks but almost no double-strand breaks, putting them in a pre-cancerous senescent state.

A catalogue of associations between DNA methylation and gene expression in children will improve the interpretation of Epigenome-Wide Association Studies.

Yuxisaurus represents the first unambiguous armored dinosaur to be recovered from the Lower Jurassic of Asia, confirming the rapid geographic spread and diversification of the armored dinosaurs throughout the northern hemisphere early in their evolution.

Comparison of human spinal cord rosette differentiation in vitro and following transplantation into heterologous embryonic environments, reveals cell-intrinsic constraint on human differentiation pace and the importance of timely extrinsic signalling for progression through an intrinsic human neural differentiation programme.

The parabrachial nucleus-thalamic paraventricular nucleus pathway is critical for modulating affective states in mice.

Mitochondrial metabolic fluxes display a subcellular spatial gradient within a single mouse oocyte, and the fluxes are not controlled by nutrient supply or energy demand of the cell, but by the intrinsic rates of mitochondrial respiration.