Affinity measurements of microRNA sites representing >1000 different pairing architectures reveal that two binding modes can mediate pairing to the microRNA 3′ region, and that microRNA G and oligo(G/C) residues are most impactful.
Long-term increased risks of arrhythmia and heart failure were found in breast cancer patients, while systemic adjuvant therapies including trastuzumab and anthracyclines were associated with the increased risk of heart failure.
A novel pathway from the deep entorhinal cortex to the hippocampus suggests that the hippocampal–neocortical loop is supported by a feedback projection from the entorhinal deep layers that copies entorhinal output to the hippocampus.
Nicolás Mongiardino Koch, Jeffrey R Thompson ... Greg W Rouse
Phylogenomics of sea urchins clarifies their origins and diversification history, reveals surprising discrepancies with their rich fossil record, and serves as basis to explore the sensitivity of time calibration analysis.
Retinoic acid signaling from Muller glia is necessary for cone photoreceptor survival in the peripheral retina and is sufficient to promote cone survival in the central retina during retinal degeneration.
A neuroprotective role mediated by Strip1 maintains retinal ganglion cells during development, which ensures proper positioning of inner retinal neurons and preserves the laminar architecture of the inner retina.
Chiara Piantoni, Manuel Paina ... Mirko Baruscotti
A Traditional Chinese Medicine botanical drug exerts a competitive antagonism on the cAMP-induced modulation of sinoatrial node pacemaker channels and this functional inhibition reduces the slope of the diastolic depolarization hence spontaneous cell automaticity.
