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Linker histone H1 and cytosine DNA methylation in contexts other than CG explain patterns of 24 nucleotide small RNA biogenesis in Arabidopsis thaliana.

Structures of the human ataxia-telangiectasia mutated (ATM) kinase alone and bound to the C-terminus of Nbs1 show the mechanisms underlying ATM autoinhibition and binding by a portion of the Mre11-Rad50-Nbs1 (MRN) activating complex.

Environmental selection overwhelmed the geographic 'distance' effect when across biotas, overturning the previously well-accepted geographic pattern for microbes on a large scale.

Structured RNA elements bind to the human methyltransferase like-3 (METTL3)-METTL14 enzyme complex with high affinity and restrict the formation of N⁶-deoxymethyladenosine in DNA.

A single origin–recognition complex (ORC) directs loading of a pair of head-to-head Mcm2-7 replicative DNA helicases by forming a protein tether to the first helicase, releasing from its initial DNA-binding site, and rebinding the origin DNA in the opposite orientation.

Celastrol covalently inhibited the chaperone activity of GRP78 and could disconnect the transduction of ER stress signal to downstream inflammatory response and lipid metabolism.

KIF2C plays an important role in synaptic plasticity and cognition behaviors in mice by regulating activity-dependent microtubule dynamic.

Zebrafish embryo screen utilizing conserved mechanisms between cancer metastasis and zebrafish gastrulation identifies the HTR2C inhibitor pizotifen as anti-metastasis drugs.

A 3.1 Å structure of cytoplasmic dynein-1 in complex with its regulator Lis1 reveals the interfaces between dynein and Lis1, all of which are important for dynein function in vitro and in vivo.

While semantic symptoms in fronto-temporal dementia patients were mainly dependent on short-range white-matter fibre disruption, long-range white-matter fibres damage was the major contributor to executive dysfunction, highlighting the importance of controlling for risk factors associated with deep white-matter disease.