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A robust automatic sleep-staging algorithm offers a high level of accuracy matching that of typical human interscorer agreement.

Inhibitory synaptic plasticity provides a flexible and biologically plausible circuit mechanism to detect the novelty of bottom-up stimuli and to generate stimulus-specific adaptation.

A theory of gut bacterial aggregation produces a cluster size distribution that matches that of several strains observed in zebrafish, suggesting principles generally applicable to the vertebrate gut.

Using single-cell CITE-seq to implicate monocytes as the cellular origin of a protective HIV vaccine gene signature.

Functional analyses of in vitro fertilized, preimplanation human embryos reveal that the first lineage segregation depends on cell polarization signaling that is regulated by Phospholipase C (PLC) activity.

The transcription factor Xrp1 mediates a previously unrecognized branch of stress-response signaling, specifically as a downstream effector of eIF2alpha kinases.

A novel retinal ganglion cell requires a cell adhesion molecule to grow its dendrites, collect synaptic inputs, and become selective to edges placed in its receptive field.

Extracellular vesicles are proposed as novel, non-cell-autonomous mediators of neuronal atrophy in Parkinson's disease.

Descriptions, examples, and tools to enable biologists to use the Common Workflow Language for data processing and to facilitate computational reproducibility.

Irreversible differentiation into somatic cells is evolutionarily optimal if changing cell phenotype is costly, a few somatic cells already improve the organism's performance, and the organism is large enough.