Browse our latest research

Page 802 of 1,737
    1. Cell Biology
    2. Microbiology and Infectious Disease

    HIV-1 uncoating by release of viral cDNA from capsid-like structures in the nucleus of infected cells

    Thorsten G Müller, Vojtech Zila ... Hans-Georg Kräusslich
    HIV-1 capsids enter the host cell nucleus, where they are partially disrupted to release the viral genome upon completion of reverse transcription.
    1. Neuroscience

    Sniff-synchronized, gradient-guided olfactory search by freely moving mice

    Teresa M Findley, David G Wyrick ... Matthew C Smear
    To track odors borne on turbulent airflow, mice strategically follow their nose, with sampling movements and sensory computations reminiscent of those demonstrated in nematodes and insects.
    1. Neuroscience

    Anticipation of temporally structured events in the brain

    Caroline S Lee, Mariam Aly, Christopher Baldassano
    The brain contains a hierarchy of anticipatory signals, with more anterior regions showing anticipation that reaches further into the future.
    1. Epidemiology and Global Health
    2. Medicine

    An agnostic study of associations between ABO and RhD blood group and phenome-wide disease risk

    Torsten Dahlén, Mark Clements ... Gustaf Edgren
    The relationship between blood groups and disease is detangled, without preconceived ideas, using population-wide data, with millions of participants and lifetime follow-up, identifying not only previously known relationships but also new insights.
    1. Evolutionary Biology

    Rampant tooth loss across 200 million years of frog evolution

    Daniel J Paluh, Karina Riddell ... David C Blackburn
    Teeth are maintained in two amphibian groups (caecilians and salamanders) but were lost in frogs over 20 times independently, a higher incidence of edentulism than any other major vertebrate group.
    1. Medicine

    Miniaturized 3D bone marrow tissue model to assess response to Thrombopoietin-receptor agonists in patients

    Christian A Di Buduo, Pierre-Alexandre Laurent ... Alessandra Balduini
    A 3D bone marrow niche that reproduces megakaryocyte differentiation and ex vivo platelet production from hematopoietic progenitors and iPSCs of thrombocytopenic patients predicts individual response to Eltrombopag accurately.
    1. Neuroscience

    Presynaptic inhibition of dopamine neurons controls optimistic bias

    Nobuhiro Yamagata, Takahiro Ezaki ... Hiromu Tanimoto
    The subcellular activity of presynaptic terminals of dopamine neurons shapes the reward magnitude and memory specificity.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Systematic screening of viral and human genetic variation identifies antiretroviral resistance and immune escape link

    Huyen Nguyen, Christian Wandell Thorball ... The Swiss HIV Cohort Study
    The presence of certain HLA alleles drives the emergence or maintenance of otherwise deleterious drug-resistant mutations in patients living with HIV, even when the patient is antiretroviral treatment naïve.
    1. Structural Biology and Molecular Biophysics

    Distinct expression requirements and rescue strategies for BEST1 loss- and gain-of-function mutations

    Qingqing Zhao, Yang Kong ... Tingting Yang
    BEST1 autosomal dominant loss-of-function mutations surprisingly behave in a dominant-negative manner, whereas gain-of-function mutations exhibit a strong dominant effect that necessitates CRISPR/Cas9-mediated suppression of the endogenous mutant allele in gene therapy.
    1. Medicine

    Targeting a cell surface vitamin D receptor on tumor-associated macrophages in triple-negative breast cancer

    Fernanda I Staquicini, Amin Hajitou ... Renata Pasqualini
    A peptide motif targeting tumor-infiltrating macrophage in triple-negative breast cancer delays tumor growth and favors an antitumor immune response.