Teresa M Findley, David G Wyrick ... Matthew C Smear
To track odors borne on turbulent airflow, mice strategically follow their nose, with sampling movements and sensory computations reminiscent of those demonstrated in nematodes and insects.
The relationship between blood groups and disease is detangled, without preconceived ideas, using population-wide data, with millions of participants and lifetime follow-up, identifying not only previously known relationships but also new insights.
Daniel J Paluh, Karina Riddell ... David C Blackburn
Teeth are maintained in two amphibian groups (caecilians and salamanders) but were lost in frogs over 20 times independently, a higher incidence of edentulism than any other major vertebrate group.
Christian A Di Buduo, Pierre-Alexandre Laurent ... Alessandra Balduini
A 3D bone marrow niche that reproduces megakaryocyte differentiation and ex vivo platelet production from hematopoietic progenitors and iPSCs of thrombocytopenic patients predicts individual response to Eltrombopag accurately.
Huyen Nguyen, Christian Wandell Thorball ... The Swiss HIV Cohort Study
The presence of certain HLA alleles drives the emergence or maintenance of otherwise deleterious drug-resistant mutations in patients living with HIV, even when the patient is antiretroviral treatment naïve.
BEST1 autosomal dominant loss-of-function mutations surprisingly behave in a dominant-negative manner, whereas gain-of-function mutations exhibit a strong dominant effect that necessitates CRISPR/Cas9-mediated suppression of the endogenous mutant allele in gene therapy.