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Neurons are mapped for developmental features (lineage, hemilineage, temporal identity) and connectomic features (morphology, synapse localization and connectivity) to reveal correlations that can be tested experimentally.

Qki-Srebp2–mediated cholesterol biosynthesis is indispensable for myelinogenesis during early brain development.

Genetic and molecular characterization showed that evolutionarily conserved flavin-containing monooxygenase (FMO-2) plays an important role in host defense in Caenorhabditis elegans, and its induction is dependent on conserved transcription factors, TFEB and PPAR-α.

Computer simulations show transitions between novel types of chromatin organization (peripheral, central, conventional) depending on chromatin interactions with itself, the lamin and nuclear hydration, measured in recent experiments.

A simple mechanism, based on the synergy of two major opposing voltage-dependent currents that are ubiquitous in neurons, produces functional diversity of developing Renshaw cells in the embryo.

A primary sensory interneuron in the thermotaxis circuit of C. elegans integrates sensory input and corollary discharge to drive persistent navigational states and movement towards preferred environments.

Identification and characterization of the responses of T lymphocytes that are specific for 'self' tissue antigens, revealing the functional limits of immune tolerance.

Mapping single-cell atlases throughout Metazoa systematically characterizes cell type diversity and the evolution of their associated gene expression programs.

Wnt distribution is regulated by a dynamic exchange of its abundant scaffold-bound and rare freely diffusing populations, providing insights into a conceived dilemma of speed and stability of tissue patterning.

The giant KASH protein ANC-1 maintains the integrity of the cytoplasm to anchor nuclei, ER, and other organelles within the cell.