Browse our latest research

Page 809 of 1,839
    1. Cancer Biology
    2. Cell Biology

    Localization of KRAS downstream target ARL4C to invasive pseudopods accelerates pancreatic cancer cell invasion

    Akikazu Harada, Shinji Matsumoto ... Akira Kikuchi
    Specific localization of KRAS downstream target ARL4C with its novel interacting proteins was the active site of invasion of pancreatic cancer cell and induced metastasis.
    1. Immunology and Inflammation

    A genetic screen in macrophages identifies new regulators of IFNγ-inducible MHCII that contribute to T cell activation

    Michael C Kiritsy, Laurisa M Ankley ... Andrew J Olive
    Med16 and GSK3b regulate interferon gamma-mediated MHCII expression in macrophages and are required for CD4+ T cell activation.
    1. Immunology and Inflammation

    Mitochondrial respiration contributes to the interferon gamma response in antigen-presenting cells

    Michael C Kiritsy, Katelyn McCann ... Andrew J Olive
    Complex I of the mitochondrial respiratory chain is necessary for interferon gamma-mediated responses in antigen-presenting cells and is required for CD4+ T cell activation.
    1. Neuroscience

    Opioid antagonism modulates wanting-related frontostriatal connectivity

    Alexander Soutschek, Susanna C Weber ... Philippe N Tobler
    Reducing activation of opioidergic receptors strengthens the communication between control and reward circuits in the brain during hedonic judgements.
    1. Cell Biology

    Control of protein synthesis and memory by GluN3A-NMDA receptors through inhibition of GIT1/mTORC1 assembly

    María J Conde-Dusman, Partha N Dey ... Isabel Perez-Otaño
    Non-conventional NMDA receptors containing GluN3A subunits place constraints on the capacity of the brain to encode lasting memories through regulation of synaptic GIT1/mTOR signaling complexes.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Unconventional conservation reveals structure-function relationships in the synaptonemal complex

    Lisa E Kursel, Henry D Cope, Ofer Rog
    The protein components of an essential and conserved meiotic interface, the synaptonemal complex, have highly conserved coil-coiled domains and protein length, despite highly diverged sequence.
    1. Neuroscience

    Urgency forces stimulus-driven action by overcoming cognitive control

    Christian H Poth
    Under time-pressure, human action is temporarily dominated by stimuli in the environment, and this results in behavior conflicting with current goals.
    1. Cell Biology
    2. Immunology and Inflammation

    mTOR-dependent translation drives tumor infiltrating CD8+ effector and CD4+ Treg cells expansion

    Benedetta De Ponte Conti, Annarita Miluzio ... Sara Ricciardi
    In the tumor microenvironment, only specific subsets of cytotoxic and immunosuppressive tumor-infiltrating lymphocytes are endowed with active translation.
    1. Evolutionary Biology

    Stronger net selection on males across animals

    Lennart Winkler, Maria Moiron ... Tim Janicke
    Comparative study provides evidence that males are under stronger total selection compared to females.
    1. Developmental Biology

    The chromatin-remodeling enzyme Smarca5 regulates erythrocyte aggregation via Keap1-Nrf2 signaling

    Yanyan Ding, Yuzhe Li ... Feng Liu
    A new zebrafish RBC aggregation model is developed to explore the dynamic process and the underlying regulatory mechanisms in blood clot formation.