Ascending and descending cortico-cortical inputs are stronger on projection neurons that project back to the source of the inputs, forming selective interareal loops in deep but not superficial cortical layers.
Leaf-cutting ants use their fecal fluid to vector enzymes produced by their fungal symbiont to degrade plant biomass with a combination of degradation enzymes and Fenton chemistry.
Emilie V Russler-Germain, Jaeu Yi ... Chyi-Song Hsieh
In vitro and in vivo studies show that multiple dendritic cell subsets are capable of presenting gut Helicobacter antigens to induce regulatory T cells.
Jaakko I Lehtimäki, Eeva Kaisa Rajakylä ... Pekka Lappalainen
Live-cell microscopy studies revealed that stress fibers can be generated de novo from the actin cortex without the involvement of stress fiber precursors.
Transsynaptic mapping of the postsynaptic connections of mushroom body output neurons reveal both divergent and convergent projections allowing for multimodal integration prior to initiation of an output response.
Hsiang-Chen Chou, Kuhulika Bhalla ... Bruce Stillman
The initiation of human genome replication requires the six-subunit origin recognition complex (ORC) and CDC6, with ORC playing additional roles during mitosis and in organization of the cell nucleus.
Bercem Dutagaci, Grzegorz Nawrocki ... Michael Feig
Charge complementarity between RNA and proteins may be a universal principle for phase separation in biology without requiring disorder or specific multivalent interactions.
Placing the PACAP/PAC1 signaling within glutamate/GABA cell type and subregional contexts in mouse brain reveals its conspicuous role for sensorimotor circuit interaction through modulating neuronal plasticity.
The first structure of a bacteriophage-encoded S-adenosyl methionine degrading enzyme was solved and demonstrated to catalyze a unimolecular lyase reaction occurring at the domain interface of a trimeric structure.
