Browse our latest research

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    1. Cell Biology
    2. Chromosomes and Gene Expression

    Cardiac endothelial cells maintain open chromatin and expression of cardiomyocyte myofibrillar genes

    Nora Yucel, Jessie Axsom ... Zoltan Arany
    Endothelial cells in the heart have transcriptional and epigenetic signatures of cardiomyocytes.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Demographic history mediates the effect of stratification on polygenic scores

    Arslan A Zaidi, Iain Mathieson
    Correction for stratification in genome-wide association studies should be informed by the demographic history of the sample.
    1. Cell Biology
    2. Medicine

    An AMPK-dependent, non-canonical p53 pathway plays a key role in adipocyte metabolic reprogramming

    Hong Wang, Xueping Wan ... Libin Liu
    A non-canonical p53 function in adipocyte plays a critical role in energy homeostasis and is involved in obesity-associated metabolic dysfunctions.
    1. Neuroscience

    Neural mechanisms underlying expectation-dependent inhibition of distracting information

    Dirk van Moorselaar, Eline Lampers ... Heleen A Slagter
    Learned expectations allow for a distinct anticipatory distractor representation at the feature but not at the spatial level.
    1. Cell Biology
    2. Neuroscience

    TFEB/Mitf links impaired nuclear import to autophagolysosomal dysfunction in C9-ALS

    Kathleen M Cunningham, Kirstin Maulding ... Thomas E Lloyd
    Impaired nuclear import of the transcription factor TFEB/MITF is a major cause of autophagy and lysosome dysfunction in amyotrophic lateral sclerosis caused by mutations in the C9orf72 gene.
    1. Cell Biology
    2. Genetics and Genomics

    A Drosophila screen identifies NKCC1 as a modifier of NGLY1 deficiency

    Dana M Talsness, Katie G Owings ... Clement Y Chow
    An ion transporter is hyperglycosylated and 50% less functional in NGLY1-deficient cells, potentially explaining several symptoms of NGLY1 deficiency such as lack of sweat and tears.
    1. Neuroscience

    Neurovascular coupling and bilateral connectivity during NREM and REM sleep

    Kevin L Turner, Kyle W Gheres ... Patrick J Drew
    Sleep-related hemodynamic signals are much larger than those in the awake brain, so it is crucial to monitor the arousal state during studies of spontaneous activity.
    1. Neuroscience

    Specific Neuroligin3–αNeurexin1 signaling regulates GABAergic synaptic function in mouse hippocampus

    Motokazu Uchigashima, Kohtarou Konno ... Kensuke Futai
    Trans-synaptic protein interactions are required for synapse specification and function, and the combination between neuroligin3 and αneurexin1 controls inhibitory synaptic function in a splice isoform- and interneuron-specific manner.
    1. Developmental Biology
    2. Neuroscience

    Cellular birthdate predicts laminar and regional cholinergic projection topography in the forebrain

    Kathryn C Allaway, William Muñoz ... Gordon Fishell
    Cholinergic populations with distinct cellular birthdates innervate deep versus superficial layers of the cortex with exquisite specificity.
    1. Cell Biology
    2. Developmental Biology

    Epidermal PAR-6 and PKC-3 are essential for larval development of C. elegans and organize non-centrosomal microtubules

    Victoria G Castiglioni, Helena R Pires ... Mike Boxem
    PAR-6 and PKC-3/aPKC are essential for postembryonic development of C. elegans and control the organization of non-centrosomal microtubule bundles in the epidermis, likely through recruitment of NOCA-1/Ninein.