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The immune Synergistic/Antagonistic Interaction Learner (iSAIL) resource has the capacity to generate insight into combinatorial immunity, help guide hypothesis generation and further experimentation relevant to basic research and drug therapeutics.

Despite the virus' error prone polymerase, influenza virus antigenic evolution is rare, even in previously immune hosts, virus replication occurs before producing new antibodies.

Neural pathways from mammalian visual cortex to ancestral brain structures control learning speed and performance of a simple detection task.

Genetic and optogenetic analyses in Drosophila neurons reveal calcium as one of the key regulators of nucleocytoplasmic localization of TDP-43 via Calpain-A and Importin α3.

Cryo preservation of brain tissue reveals dendritic spines with thinner necks compared to those prepared with chemical fixation.

The interplay between the Flower Ca²⁺ channel and PI(4,5)P₂ spatiotemporally couples synaptic vesicle exocytosis to activity-dependent bulk endocytosis and synaptic vesicle reformation from bulk endosomes.

Experiments using zebrafish identify a novel sleep-promoting neuronal circuit in which hypothalamic NPVF neurons promote sleep via the hindbrain serotonergic raphe nuclei, which promote sleep in both zebrafish and mice.

Casein kinase I, a pivotal kinase in the circadian clock encoded by ck-1a, is positively regulated by a novel RNA-binding protein that protects ck-1a transcripts from nonsense-mediated decay.

Concepts can be represented at multiple levels of specificity (individual examples, abstract category averages) within a single task across different regions of the brain.

Quantification of uncertainty in drug dose-responses provides a more robust metric for differentiating drugs and identifying biomarkers of response.