Setpoints that determine the integrative properties of neurons in the medial entorhinal cortex are established at a population level and differ between animals.
Temitayo O Idowu, Valerie Etzrodt ... Sascha David
Matrix metalloprotease (MMP)-14 cleaves Tie2 at three distinct sites within the fibronectin type-III (FN3) domain and its pharmacological blockade inhibits Tie2 pathological shedding to exert barrier protective effects.
Chaitanya A Kulkarni, Sergiy M Nadtochiy ... Paul S Brookes
Multi-omics reveals that Alkb homolog 7 (ALKBH7), α mitochondrial alpha-ketoglutarate dioxygenase of unclear function, regulates glyoxal metabolism, which may explain its role in necrosis and heart attack.
Cryo-EM structures of human MCU-EMRE-MICU1-MICU2 complex in the apo and Ca2+-bound states reveal how MICU1 and MICU2 impart their gating function to the mitochondrial calcium uniporter.
Slow, continuous changes in eye position when gaze is fixed, previously believed to be random drifts, are shown to exhibit highly systematic and short-latency response characteristics to visual stimuli.
Naotaka Tsutsumi, Somnath Mukherjee ... K Christopher Garcia
Cryo-EM structure of monomeric human Frizzled5 was determined with a universal fiducial antibody at 3.7 Å overall resolution, which supports a simple Fzd/LRP6 heterodimerization mechanism of canonical Wnt/β-catenin signaling.
Hsiang-Yu Tsai, Dustin R Rubenstein ... Sheng-Feng Shen
By integrating theoretical and empirical approaches, the results show that linking abiotic factor and biotic interactions on the niche width will be critical for understanding species-specific responses to climate change.
Targeting senescent cells in human intervertebral discs, using senotherapeutics, provides a potential therapeutic strategy to prevent or reduce disc degeneration and pain.
The formation and refinement of prediction error circuits relies on an experience-dependent balance of excitation and inhibition in canonical microcircuits.
A systemic hormone controls progenitor fate decisions independent of local fate determining pathways in the adult intestinal stem cell niche of Drosophila melanogaster..
