The aged human auditory cortex shows preserved tonotopy, but temporal modulations are represented with a markedly broader tuning, highlighting decreased temporal selectivity as a hallmark of the aging auditory cortex.
Michael R Garvin, Christiane Alvarez ... Daniel Jacobson
Gene expression analysis reveals a novel, integrated molecular mechanism for much of the pathogenesis of COVID-19 that provides therapeutic intervention points that can be addressed with existing approved pharmaceuticals.
Applying deep learning technology for the large-scale curation of symptoms from unstructured EHR clinical notes accurately predicts the differential signals of COVID-19 diagnosis over the week preceding typical PCR testing.
Aminoglycosides are a class of antibiotics that can kill Escherichia coli by building up internal voltage through disrupting the normal consumption of ATP.
An elaborated bat-predator model shows that even in high bat-densities, bats can successfully catch flying insects and that changing their signals’ frequency is not necessary for dealing with sensory interference.
One α-synuclein strain inhibited proteasome activity and induced apparent pathologies, while the other did not, indicating a strain-dependent toxicity of α-synuclein aggregates, which support a prion-like behavior of α-synuclein.
Allison N Lau, Zhaoqi Li ... Matthew G Vander Heiden
Isotope tracing into macromolecules enables functional analysis of metabolism in specific cell populations in tumors and provides insight into metabolic differences between cancer and stromal cells in their endogenous microenvironment.
Omer Faruk Gulban, Rainer Goebel ... Federico de Martino
Inter-individual human brain alignment that uses macro-anatomical priors in addition to cortical curvature improves micro-anatomical correspondence between auditory areas.
