Browse our Research Advances

Page 26 of 47
    1. Neuroscience

    Axon-dependent expression of YAP/TAZ mediates Schwann cell remyelination but not proliferation after nerve injury

    Matthew Grove, Hyunkyoung Lee ... Young-Jin Son
    YAP and TAZ, potent concoproteins and therapeutic targets in cancer therapy, are essential for Schwann cells to support peripheral nerve regeneration.
    1. Developmental Biology
    2. Neuroscience

    Temporal transcription factors determine circuit membership by permanently altering motor neuron-to-muscle synaptic partnerships

    Julia L Meng, Yupu Wang ... Ellie S Heckscher
    Acting in neuronal stem cells, temporal transcription factors, as a class of molecules, are uniquely potent determinants of circuit membership that establish expected patterns of wiring in the motor system.
    1. Neuroscience

    Synergistic actions of v-SNARE transmembrane domains and membrane-curvature modifying lipids in neurotransmitter release

    Madhurima Dhara, Maria Mantero Martinez ... Dieter Bruns
    Naturally-occurring v-SNARE TMD variants differentially regulate fusion pore dynamics and cooperate with phospholipids in supporting membrane curvature at the fusion pore neck.
    1. Cell Biology
    2. Developmental Biology

    R-spondins engage heparan sulfate proteoglycans to potentiate WNT signaling

    Ramin Dubey, Peter van Kerkhof ... Rajat Rohatgi
    Heparan Sulfate Proteoglycans function as receptors for the R-spondins, a family of growth factors that amplify the strength of WNT signaling during development and in adult stem cells.
    1. Neuroscience

    β spectrin-dependent and domain specific mechanisms for Na+ channel clustering

    Cheng-Hsin Liu, Ryan Seo ... Matthew N Rasband
    β4 spectrin is required to maintain Na+ channels at the axon initial segment since, unlike nodes of Ranvier, β1 spectrin cannot substitute.
    1. Biochemistry and Chemical Biology

    The dynamic interplay of host and viral enzymes in type III CRISPR-mediated cyclic nucleotide signalling

    Januka S Athukoralage, Shirley Graham ... Malcolm F White
    The dynamic interplay between type III CRISPR enzymes governs cyclic nucleotide levels and infection outcomes in virus-host conflict.
    1. Neuroscience

    Spatiotemporally precise optogenetic activation of sensory neurons in freely walking Drosophila

    Brian D DeAngelis, Jacob A Zavatone-Veth ... Damon A Clark
    A simple, computationally efficient method provides spatiotemporally precise optogenetic perturbations in freely walking Drosophila, revealing the asymmetries and region-specificity of behavioral programs evoked by activating mechanosensory and chemosensory neurons.
    1. Cell Biology

    STK25 suppresses Hippo signaling by regulating SAV1-STRIPAK antagonism

    Sung Jun Bae, Lisheng Ni, Xuelian Luo
    Phosphorylation-dependent regulation of SAV1-STRIPAK antagonism by STK25.
    1. Genetics and Genomics
    2. Neuroscience

    Partial loss of CFIm25 causes learning deficits and aberrant neuronal alternative polyadenylation

    Callison E Alcott, Hari Krishna Yalamanchili ... Huda Y Zoghbi
    Partial reduction of CFIm25 protein levels leads to misregulated alternative polyadenylation in neurons and learning deficits.
    1. Plant Biology
    2. Structural Biology and Molecular Biophysics

    Charting the native architecture of Chlamydomonas thylakoid membranes with single-molecule precision

    Wojciech Wietrzynski, Miroslava Schaffer ... Benjamin D Engel
    In situ cryo-electron tomography resolves individual photosynthetic complexes within native thylakoid membranes, revealing how thylakoid architecture sorts proteins into discrete membrane domains.