Emx2 is not required for sibling HCs to acquire their designated locations within the neuromast, inferring that Emx2 mediates opposite HC orientation by changing location of hair bundle establishment.
Models of chromosome compaction by condensins demonstrate that two-sided loop extrusion and long residence times are required for high compaction, suggesting a tight coupling between these two properties in vivo.
Daniel A Lee, Grigorios Oikonomou ... David A Prober
Experiments using zebrafish identify a novel sleep-promoting neuronal circuit in which hypothalamic NPVF neurons promote sleep via the hindbrain serotonergic raphe nuclei, which promote sleep in both zebrafish and mice.
A disinhibitory motif in the retina mediates noise resilience of motion detection using an inverted algorithm of disinhibition due to the interplay between network activity and synaptic plasticity.
Xiaowei Hou, Ian R Outhwaite ... Stephen Barstow Long
Structure of the Ca2+ channel Orai in an open conformation provides insights into the opening mechanism and the channel's role in regulating Ca2+ entry into immune and other non-excitable cells.
TANGO1 functions as a linactant filament to stabilize shallow COPII-coated buds, and after which membrane tension regulation, possibly mediated by TANGO1-controlled membrane fusion, facilitates bud elongation for procollagen export.
In monkeys making decisions that balance noisy evidence and reward expectation, frontal cortical and caudate activity reflect different computational components that are related to the monkeys' strategy.
