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The reduced ability of Drosophila imaginal discs to regenerate as they mature can be explained by the silencing of damage-responsive enhancers that regulate expression of genes required for regeneration.

Across species and domains of decision-making, pupil-linked phasic arousal predicts suppression biases in the accumulation of evidence leading up to a choice.

Fruit flies fed with high-fats diets are hyper-sensitive to a hunger hormone AKH and exhibit enhanced food-seeking behavior when starved.

TANGO1 creates a barrier to control lipid and protein flux across fused secretory compartments.

YAP and TAZ, potent concoproteins and therapeutic targets in cancer therapy, are essential for Schwann cells to support peripheral nerve regeneration.

Acting in neuronal stem cells, temporal transcription factors, as a class of molecules, are uniquely potent determinants of circuit membership that establish expected patterns of wiring in the motor system.

Naturally-occurring v-SNARE TMD variants differentially regulate fusion pore dynamics and cooperate with phospholipids in supporting membrane curvature at the fusion pore neck.

Heparan Sulfate Proteoglycans function as receptors for the R-spondins, a family of growth factors that amplify the strength of WNT signaling during development and in adult stem cells.

β4 spectrin is required to maintain Na+ channels at the axon initial segment since, unlike nodes of Ranvier, β1 spectrin cannot substitute.

The dynamic interplay between type III CRISPR enzymes governs cyclic nucleotide levels and infection outcomes in virus-host conflict.