Browse our Research Advances

Page 4 of 44
    1. Neuroscience

    Competing neural representations of choice shape evidence accumulation in humans

    Krista Bond, Javier Rasero ... Timothy Verstynen
    Interactions between cortical and subcortical circuits in the mammalian brain flexibly control the flow of information streams that drive decisions by shifting the balance of power both within and between action representations.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Molecular tuning of sea anemone stinging

    Lily S He, Yujia Qi ... Nicholas W Bellono
    Sea anemones use adapted ion channels to control stinging behavior.
    1. Ecology
    2. Genetics and Genomics

    Adulis and the transshipment of baboons during classical antiquity

    Franziska Grathwol, Christian Roos ... Gisela H Kopp
    The first sequenced mitogenome of a mummified non-human primate connects an Egyptian baboon dated to ca. 800–540 BCE to modern baboon populations in Eritrea, Ethiopia, and eastern Sudan, providing evidence for Egyptian–Adulite trade centuries earlier than current archaeological evidence.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    The Calpain-7 protease functions together with the ESCRT-III protein IST1 within the midbody to regulate the timing and completion of abscission

    Elliott L Paine, Jack J Skalicky ... Wesley I Sundquist
    Biochemical, structural, imaging, and functional studies reveal how the ESCRT-III protein IST1 recruits the CAPN7 cysteine protease to midbodies, where its proteolytic activity is required for efficient abscission and NoCut checkpoint arrest.
    1. Biochemistry and Chemical Biology

    GDF15 is required for cold-induced thermogenesis and contributes to improved systemic metabolic health following loss of OPA1 in brown adipocytes

    Jayashree Jena, Luis Miguel García-Peña ... Renata O Pereira
    Deletion of optic atrophy 1 in brown adipose tissue induces secretion of growth differentiation factor 15 as a batokine to attenuate diet-induced obesity and improve glucose clearance, hepatic steatosis, and thermoregulation in mice by increasing energy expenditure.
    1. Structural Biology and Molecular Biophysics

    Allosteric inhibition of the T cell receptor by a designed membrane ligand

    Yujie Ye, Shumpei Morita ... Francisco N Barrera
    A designer peptide inhibits the T cell receptor through allosteric binding to the transmembrane region.
    1. Epidemiology and Global Health
    2. Medicine

    Development and validation of COEWS (COVID-19 Early Warning Score) for hospitalized COVID-19 with laboratory features: A multicontinental retrospective study

    Riku Klén, Ivan A Huespe ... David Gómez-Varela
    The new early warning system, COEWS, will improve the early identification and management of high-risk COVID-19 patients compared to the widely used NEWS2 by using easy-to-obtain clinical parameters that have been externally validated in a diverse multicontinental cohort of patients.
    1. Developmental Biology

    Comparative single-cell profiling reveals distinct cardiac resident macrophages essential for zebrafish heart regeneration

    Ke-Hsuan Wei, I-Ting Lin ... Shih-Lei (Ben) Lai
    An extensive characterization of inflammatory cell dynamics, function, and potential interaction during zebrafish cardiac repair identified specific resident macrophage subsets function in debris clearance, inflammatory resolution, and extracellular matrix remodeling, indispensable for successful heart regeneration.
    1. Neuroscience

    Nested circuits mediate the decision to vocalize

    Shuyun Xiao, Valerie Michael, Richard Mooney
    The decision to vocalize depends on neural circuits that balance the rewards of potential social affiliation with the risks of advertising.
    1. Neuroscience

    Inconsistencies between human and macaque lesion data can be resolved with a stimulus-computable model of the ventral visual stream

    Tyler Bonnen, Mark AG Eldridge
    A 'stimulus-computable' modeling approach resolves apparent inconsistencies between human and monkey lesion data, implicating perirhinal cortex in visual object perception.