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Reserpine, previously identified through high-throughput screening in CEP290 retinal degeneration models, enhances photoreceptor survival in P23H rhodopsin retinal degeneration models, particularly in female rats, indicating its gene-agnostic and sex-specific effectiveness.

The asymmetrically segregated Notch pathway inhibitor Numb is essential for intestinal stem cell self-renewal in adult Drosophila midguts when the stem cell niche signaling is compromised.

Recognition of antigenic ligand by T-cell receptors is a nuanced process where mechanical force can be leveraged to diversify functional outcomes of different T-cells for the same ligand.

A more complete, bidirectional relationship between fear conditioning and behavior is established when many behaviors are examined, as opposed to single behavior such as freezing.

Infants are sensitive to their own respiration and heartbeat already in the first two years of life.

The amygdala and perirhinal cortex work together to integrate sensory and emotional information under a range of different circumstances.

Gene duplication in antibiotic-resistant bacteria mitigates elevated demand for expression, facilitating adaptation to antibiotics and alleviating costs of proteolytic instability of the drug target.

Centriolar triplet microtubules are required for the formation and positioning of centriole substructures.

The reward signal dopamine modulates synaptic plasticity by increasing protein synthesis, revealing a potential molecular mechanism for long-term memory storage.

An optimized cytosine base editing system for Leishmania species improves editing efficiency, reduces toxicity, and ensures stable guide expression, enabling scalable loss-of-function screening and efficient creation of functional mutants.