Flow hemodynamic activation of endothelial klf2a is a mechanism regulating initial vascular smooth muscle cell differentiation on circle of Willis arteries.
Molecular mechanism that Candidatus Liberibacter asiaticus improves the lipid metabolism and fecundity of Diaphorina citri through adipokinetic hormone and its receptor.
Nicholas LaBerge, Kenneth Hunter Wapman ... Daniel B Larremore
Achieving gender parity among U.S. tenured and tenure-track faculty will require changes to hiring, which has substantially greater impacts on faculty gender representation than gendered differences in attrition rates.
Statistical learning shapes pain perception by allowing the brain to predict and modulate pain intensity based on temporal patterns, providing insights into pain regulation and their relevance to chronic pain.
Ladan Shahshahani, Maedbh King ... Jörn Diedrichsen
The human cerebellum shows fMRI activity for many tasks – however, the inputs from the neocortex are upregulated in a task-dependent manner when cerebellar computation is required.
When exposed to high-dose ionizing radiation, tardigrades undergo extensive DNA damage, like humans, but cope by stimulating expression of DNA repair proteins and of TDR1, a novel tardigrade-specific DNA-binding protein.
Rajdeep Banerjee, Thomas J Meyer ... David D Roberts
Increased extramedullary erythropoiesis in spleen compensates for the elevated turnover of red blood cells in mice lacking CD47, but extramedullary erythropoiesis is suppressed in mice lacking the CD47 ligand thrombospondin-1.
Indoxyl sulfate, a key uremic toxin in chronic kidney disease (CKD), induces trained immunity in monocytes via crosstalk between aryl hydrocarbon receptor (AhR)-dependent epigenetic reprogramming by enhancement of the arachidonic acid pathway and AhR-independent metabolic rewiring.
A prognostic model constructed based on RNA-sequencing and clinical specimens analyses reveals VCAN, C1QB, and CD3G could be key factors in modulating tumor microenviornment of DLBCL.
