Zahid Padamsey, Danai Katsanevaki ... Nathalie L Rochefort
Multi-scale analysis of mouse visual cortex reveals a sex-specific difference in response to long-term food restriction, with males being more impacted than females.
Petteri Stenroos, Isabelle Guillemain ... Emmanuel L Barbier
Rats with absence epilepsy exhibit hindered and restricted sensory processing during ongoing seizures, as demonstrated by functional magnetic resonance imaging and mean-field simulation studies.
Carlo Giannangelo, Matthew P Challis ... Darren J Creek
M1 alanyl aminopeptidase is chemically validated as an attractive antimalarial target by confirming the on-target activity of a novel selective inhibitor using chemoproteomics and metabolomics-based drug target deconvolution approaches.
Nicholas J Mullen, Surendra K Shukla ... Pankaj K Singh
Cancer cell antigen presentation, a requirement for immune-mediated tumor rejection, is induced by dihydroorotate dehydrogenase-inhibitor-mediated cancer cell pyrimidine nucleotide depletion via P-TEFb-dependent transcriptional upregulation of MHC-I and related genes.
The first structural and biochemical study of the role of the ATP-cone in anaerobic ribonucleotide reductases shows that dATP allosterically prevents transfer of a glycyl radical to the substrate.
High-level visual cortex and leading neural network models of the visual system retain information about multiple visual scene variables in independent, non-interfering dimensions of their population codes.
TRPV4 and ANO1 are co-expressed in the sweat glands of mouse food pads and found to be involved in perspiration, suggesting that local temperature sensation through TRPV4 could control seating.