Browse our Research Articles

Page 116 of 1,380
    1. Neuroscience

    Sex-specific resilience of neocortex to food restriction

    Zahid Padamsey, Danai Katsanevaki ... Nathalie L Rochefort
    Multi-scale analysis of mouse visual cortex reveals a sex-specific difference in response to long-term food restriction, with males being more impacted than females.
    1. Neuroscience

    EEG-fMRI in awake rat and whole-brain simulations show decreased brain responsiveness to sensory stimulations during absence seizures

    Petteri Stenroos, Isabelle Guillemain ... Emmanuel L Barbier
    Rats with absence epilepsy exhibit hindered and restricted sensory processing during ongoing seizures, as demonstrated by functional magnetic resonance imaging and mean-field simulation studies.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Chemoproteomics validates selective targeting of Plasmodium M1 alanyl aminopeptidase as an antimalarial strategy

    Carlo Giannangelo, Matthew P Challis ... Darren J Creek
    M1 alanyl aminopeptidase is chemically validated as an attractive antimalarial target by confirming the on-target activity of a novel selective inhibitor using chemoproteomics and metabolomics-based drug target deconvolution approaches.
    1. Cancer Biology
    2. Immunology and Inflammation

    DHODH inhibition enhances the efficacy of immune checkpoint blockade by increasing cancer cell antigen presentation

    Nicholas J Mullen, Surendra K Shukla ... Pankaj K Singh
    Cancer cell antigen presentation, a requirement for immune-mediated tumor rejection, is induced by dihydroorotate dehydrogenase-inhibitor-mediated cancer cell pyrimidine nucleotide depletion via P-TEFb-dependent transcriptional upregulation of MHC-I and related genes.
    Version of Record
    Research Article
    • Important
    • Compelling
    • Incomplete
    1. Neuroscience

    Early parafoveal semantic integration in natural reading

    Yali Pan, Steven Frisson ... Ole Jensen
    During natural reading, before we fixate on a word, we can already extract its meaning and even integrate it into the evolving context.
    1. Biochemistry and Chemical Biology

    Nucleotide binding to the ATP-cone in anaerobic ribonucleotide reductases allosterically regulates activity by modulating substrate binding

    Ornella Bimai, Ipsita Banerjee ... Derek T Logan
    The first structural and biochemical study of the role of the ATP-cone in anaerobic ribonucleotide reductases shows that dATP allosterically prevents transfer of a glycyl radical to the substrate.
    1. Neuroscience

    Factorized visual representations in the primate visual system and deep neural networks

    Jack W Lindsey, Elias B Issa
    High-level visual cortex and leading neural network models of the visual system retain information about multiple visual scene variables in independent, non-interfering dimensions of their population codes.
    1. Cell Biology

    Involvement of TRPV4 in temperature-dependent perspiration in mice

    Makiko Kashio, Sandra Derouiche ... Makoto Tominaga
    TRPV4 and ANO1 are co-expressed in the sweat glands of mouse food pads and found to be involved in perspiration, suggesting that local temperature sensation through TRPV4 could control seating.
    1. Neuroscience

    The breath shape controls intonation of mouse vocalizations

    Alastair MacDonald, Alina Hebling ... Kevin Yackle
    The breathing motor program is re-engaged to control the fluctuations in vocal pitch during a sound.
    1. Neuroscience

    Perceptual error based on Bayesian cue combination drives implicit motor adaptation

    Zhaoran Zhang, Huijun Wang ... Kunlin Wei
    Model based on Bayesian cue combination shows that procedural motor learning is driven by perceptual error in localizing one's effector.