Browse our Research Articles

The genetic 'fossil record' of a retroviral lineage over >25 million years of evolution reveals the profound consequences of an ancient recombination event on viral replication mechanisms and genome structure, and identifies an ancient interspecies viral transmission.

AlphaFold2's inability to generate non-native conformations for docking is addressed by AI-molecular dynamics method AlphaFold2-RAVE, which produces Boltzmann-ranked conformations, enabling the retrospective discovery of type II kinase inhibitors.

Prothoracicotropic hormone and ecdysone belonging to the insect PG axis modulate virgin female sexual receptivity.

Proteins evolve more intrinsic structural disorder under more effective selection, with selection assessed via a novel metric of codon adaptation.

The timescale dependence of d_N/d_S in bacteria is better explained by adaptive than purifying dynamics, suggesting comparative genomics can underestimate past adaptation.

Early moderate consumption of alcohol in pregnancy was sufficient to disrupt the fetal epigenome in newborn mice, and high folate maternal diets had a mitigating effect.

Applying deep learning tools to pinpoint predictive gaps in behavioral cognitive modeling.

A new native prion protein aggregation assay shows that syntaxin-6, a risk factor for sporadic Creutzfeldt–Jakob disease, delays prion protein fibril formation and prolongs the presence of toxic aggregation intermediates.

Fast calcium dynamics of honey bee olfactory projection neurons revealed an unprecedented heterogeneity of response profile dynamics and explained fundamental aspects of olfactory discrimination and associative learning.

A novel in vivo role for miRNAs Mir221/222 in arthritogenic synovial fibroblasts and progression of arthritis is presented.