Browse our Research Articles

Page 123 of 1,380
    1. Computational and Systems Biology
    2. Epidemiology and Global Health

    Reliance on self-reports and estimated food composition data in nutrition research introduces significant bias that can only be addressed with biomarkers

    Javier I Ottaviani, Virag Sagi-Kiss ... Gunter GC Kuhnle
    The reliance on food composition databases for the assessment of dietary intake is unreliable and results in a large bias when investigating the associations between diet and disease risk.
    1. Plant Biology

    Distinct effects of phyllosphere and rhizosphere microbes on invader Ageratina adenophora during its early life stages

    Zhao-Ying Zeng, Jun-Rong Huang ... Han-Bo Zhang
    An inoculation experiment shows phyllosphere microbiome plays an important role in invader Ageratina adenophora population establishment by killing seedlings at very early growth stage.
    1. Chromosomes and Gene Expression

    Transcriptional immune suppression and up-regulation of double-stranded DNA damage and repair repertoires in ecDNA-containing tumors

    Miin S Lin, Se-Young Jo ... Vineet Bafna
    Extrachromosomal DNA containing tumors up-regulate DNA damage and repair, cell cycle control, and mitotic processes, but down-regulate global immune regulation pathways, suggesting new avenues for therapeutic intervention.
    1. Cancer Biology
    2. Computational and Systems Biology

    Optimal transport for automatic alignment of untargeted metabolomic data

    Marie Breeur, George Stepaniants ... Vivian Viallon
    A computational method based on optimal transport enables state-of-the-art alignment between untargeted metabolomic studies and is evaluated on cord blood and cancer datasets.
    1. Cancer Biology
    2. Cell Biology

    SOD1 is a synthetic-lethal target in PPM1D-mutant leukemia cells

    Linda Zhang, Joanne I Hsu ... Margaret A Goodell
    PPM1D-mutant leukemia cells exhibit a dysregulated redox landscape, a diminished response to oxidative stress, and rely on SOD1 for their survival.
    1. Physics of Living Systems

    Diffusive lensing as a mechanism of intracellular transport and compartmentalization

    Achuthan Raja Venkatesh, Kathy H Le ... Onn Brandman
    Agent-based modeling of space-dependent diffusivity inside cells reveals potential effects on biomolecule concentration and mesoscale dynamics.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    ASAR lncRNAs control DNA replication timing through interactions with multiple hnRNP/RNA binding proteins

    Mathew Thayer, Michael B Heskett ... Phillip A Yates
    Molecular genetic analyses of ASARs reveals regulation of large-scale mammalian chromosome structure and function that includes long non-coding RNAs and nuclear RNA binding proteins as essential regulators of chromosome dynamics.
    1. Plant Biology

    A dual function of the IDA peptide in regulating cell separation and modulating plant immunity at the molecular level

    Vilde Olsson Lalun, Maike Breiden ... Melinka A Butenko
    A molecular investigation on the role of the peptide ligand inflorescence deficient in abscission (IDA) in regulating immunity and development during cell separation in Arabidopsis thaliana.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Structural analysis of the dynamic ribosome-translocon complex

    Aaron JO Lewis, Frank Zhong ... Ramanujan S Hegde
    A combination of cryo-electron microscopy, structure prediction, and evolutionary analyses reveal several functional states of the dynamic protein translocation machinery at the mammalian endoplasmic reticulum.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Tribbles1 is host protective during in vivo mycobacterial infection

    Ffion R Hammond, Amy Lewis ... Philip M Elks
    The pseudokinase Tribbles1 is expressed in human monocytes after mycobacterial challenge and can be manipulated to be host protective against mycobacterial infection, due to control of innate immune cell function, in a zebrafish tuberculosis model.