Browse our Research Articles

Page 126 of 1,404
    1. Medicine
    2. Neuroscience

    Interrogating basal ganglia circuit function in people with Parkinson’s disease and dystonia

    Srdjan Sumarac, Kiah A Spencer ... Luka Milosevic
    The hypo- versus hyperkinetic nature of Parkinson’s disease and dystonia, respectively, may be reflected by differences in disease-specific spiketrain dynamics and striato-pallidal synaptic plasticity.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Association with TFIIIC limits MYCN localisation in hubs of active promoters and chromatin accumulation of non-phosphorylated RNA polymerase II

    Raphael Vidal, Eoin Leen ... Gabriele Büchel
    MYCN and TFIIIC exert a censoring function during early transcription, limiting the accumulation of inactive RNAPII at the promoter and facilitating promoter-proximal degradation of nascent RNA.
    1. Medicine

    Drosophila model to clarify the pathological significance of OPA1 in autosomal dominant optic atrophy

    Yohei Nitta, Jiro Osaka ... Atsushi Sugie
    Dominant optic atrophy (DOA) and DOA plus mutations' effects on optic nerve degeneration distinguished in a novel Drosophila model.
    1. Developmental Biology
    2. Genetics and Genomics

    The role of heterochronic gene expression and regulatory architecture in early developmental divergence

    Nathan D Harry, Christina Zakas
    Changes in the amount and timing of gene expression during early development contribute to evolutionary divergence and life-history changes, even within a species.
    1. Neuroscience

    Task-specific invariant representation in auditory cortex

    Charles R Heller, Gregory R Hamersky, Stephen V David
    Engagement in auditory detection task leads to selective enhancement of task relevant information by neural populations in higher order auditory cortex.
    1. Epidemiology and Global Health

    Associations of age at diagnosis of breast cancer with incident myocardial infarction and heart failure: A prospective cohort study

    Jie Liang, Yang Pan ... Fanfan Zheng
    Younger age at diagnosis of breast cancer was associated with higher risks of incident myocardial infarction and heart failure.
    1. Neuroscience

    A ‘double-edged’ role for type-5 metabotropic glutamate receptors in pain disclosed by light-sensitive drugs

    Serena Notartomaso, Nico Antenucci ... Volker Neugebauer
    Photopharmacological manipulations of mGlu5 receptors with light-sensitive negative allosteric modulators show brain region-specific roles in pain modulation and suggest that blockade of mGlu5 receptors in the amygdala may limit the overall analgesic activity of mGlu5 receptor antagonists.
    1. Developmental Biology

    FBXO24 deletion causes abnormal accumulation of membraneless electron-dense granules in sperm flagella and male infertility

    Yuki Kaneda, Haruhiko Miyata ... Masahito Ikawa
    FBXO24, a testis-enriched E3 ubiquitin ligase, is essential for sperm flagellum formation and male fertility in mice.
    1. Chromosomes and Gene Expression

    Target-specific requirements for RNA interference can arise through restricted RNA amplification despite the lack of specialized pathways

    Daphne R Knudsen-Palmer, Pravrutha Raman ... Antony M Jose
    Experimental results and computational modeling reveal many factors that influence if a gene can be efficiently silenced using RNA interference.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Released bacterial ATP shapes local and systemic inflammation during abdominal sepsis

    Daniel Spari, Annina Schmid ... Guido Beldi
    Bacteria release ATP as part of their attack in sepsis.