A combined theoretical and experimental study revealed the mechanistic and structural basis of mutational effects on allostery and provided insights into the intrinsic connection of intra- and inter-domain properties.
Ivan Castello-Serrano, Frederick A Heberle ... Ilya Levental
Direct measurements of trafficking kinetics between organelles of the secretory pathway suggest that lipid-driven membrane domains laterally sort proteins during membrane traffic.
Conditional abolishment of a G protein subunit in a subset of ectopic tuft cells engenders severer injury, slower recovery, and increased fatality following the infection of the influenza viruses.
Pascal Forcella, Niklas Ifflander ... Verdon Taylor
Extensive analysis shows that the RNA-binding protein SAFB binds to Drosha in hippocampal stem cells and controls oligodendrocyte fate commitment through post-transcriptional regulation of NFIB expression.
The autophagosomal membrane becomes negatively charged during maturation due to the accumulation of PI4P, leading to the recruitment of syntaxin 17, which is required for autophagosome-lysosome fusion.
Escherichia coli exhibits sensitive chemotaxis to potassium, mediated by differential responses of Tar and Tsr chemoreceptors to intracellular pH changes induced by potassium concentration gradients.
Individual olfactory-driven behaviors, odor preferences, and olfactory sensitivity have rapidly evolved in blind Mexican cavefish, as a quantitative genetic trait.
The first neurodevelopmental study using a novel, wearable brain imaging system based on optically pumped magnetometers, shows age-related changes in neural oscillatory task responses and cortical functional connectivity.
Rafael F Guerrero, Tandin Dorji ... C Brandon Ogbunugafor
Inspired by notions of 'druggability' from medicinal chemistry, two new metrics, drug applicability and variant vulnerability, utilize evolutionary perspectives and methods to improve attempts to treat infectious diseases.
