Individual olfactory-driven behaviors, odor preferences, and olfactory sensitivity have rapidly evolved in blind Mexican cavefish, as a quantitative genetic trait.
The first neurodevelopmental study using a novel, wearable brain imaging system based on optically pumped magnetometers, shows age-related changes in neural oscillatory task responses and cortical functional connectivity.
Rafael F Guerrero, Tandin Dorji ... C Brandon Ogbunugafor
Inspired by notions of 'druggability' from medicinal chemistry, two new metrics, drug applicability and variant vulnerability, utilize evolutionary perspectives and methods to improve attempts to treat infectious diseases.
Giuseppina Porciello, Alessandro Monti ... Salvatore Maria Aglioti
Direct measures of inner gastrointestinal signals via ingestible capsules highlight the role of stomach pH in shaping human feelings of disgust, fear and happiness.
Rupam Choudhury, Anuroop Venkateswaran Venkatasubramani ... Axel Imhof
Proximity biotinylation of the Drosophila centromere suggests a role of RNA helicases, centromeric transcripts, and centromeric R-loops for centromere function.
DUX4 expression is a common feature of metastatic tumors, where it is significantly associated with immune cell exclusion, decreased objective response to immune checkpoint blockade, and reduced patient survival.
Fanny-Mei Cloarec-Ung, Jamie Beaulieu ... David JHF Knapp
Precision genome editing in human hematopoietic stem and progenitor cells can achieve near-perfect efficiency with tunable zygosity, thus enabling isogenic disease modeling for monogenic blood disorders and improving therapeutic applications.
Caroline Krag, Maria Saur Svane ... Tinne Laurberg
Treatment of colorectal cancer with colonic resection compared with rectal resection results in sligthly increased T2D risk, whereas chemotherapy treatment does not impact risk of developing T2D.
Styxl2, a sarcomeric muscle-specific pseudophosphatase in vertebrates, functions in sarcomere assembly by promoting protein degradation of non-muscle myosin IIs.