Browse our Research Articles

Page 14 of 1,343
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Telomere length sensitive regulation of interleukin receptor 1 type 1 (IL1R1) by the shelterin protein TRF2 modulates immune signalling in the tumour microenvironment

    Ananda Kishore Mukherjee, Subhajit Dutta ... Shantanu Chowdhury
    Telomere-sensitive regulation of IL1R1 by the shelterin protein TERF2 modulates tumour macrophage inflitration in triple-negative breast cancer.
    1. Neuroscience

    Learning enhances behaviorally relevant representations in apical dendrites

    Sam E Benezra, Kripa B Patel ... Randy M Bruno
    Reinforcement learning produces long-lasting realignment of layer 1 apical dendrite tuft responses to behaviorally relevant task dimensions, both rewarded and unrewarded.
    1. Cell Biology

    Constitutively active receptor ADGRA3 signaling induces adipose thermogenesis

    Zewei Zhao, Longyun Hu ... Zhonghan Yang
    ADGRA3 signaling promotes adipose thermogenesis via Gs-PKA-CREB, suggesting hesperetin and ADGRA3 overexpression as obesity therapies.
    1. Neuroscience

    Bridging the gap between presynaptic hair cell function and neural sound encoding

    Lina María Jaime Tobón, Tobias Moser
    Synaptic diversity in the ear's inner hair cells significantly empowers sound encoding to enable our processing of sounds across a broad range of intensities.
    1. Neuroscience

    The satiety hormone cholecystokinin gates reproduction in fish by controlling gonadotropin secretion

    Lian Hollander-Cohen, Omer Cohen ... Berta Levavi-Sivan
    Genetic loss-of-function approaches and functional calcium imaging reveal cholecystokinin as the primary regulator of follicle-stimulating hormone in zebrafish, redefining our understanding of gonadotropin regulation in vertebrates.
    1. Cancer Biology

    Improving PD-1 blockade plus chemotherapy for complete remission of lung cancer by nanoPDLIM2

    Fan Sun, Pengrong Yan ... Zhaoxia Qu
    The novel PDLIM2 nanomedicine enhances chemoimmunotherapy for complete cure of lung cancer.
    1. Neuroscience

    CaBP1 and 2 enable sustained CaV1.3 calcium currents and synaptic transmission in inner hair cells

    David Oestreicher, Shashank Chepurwar ... Tina Pangrsic
    Analysis of Cabp1/2 double knockout phyenotype and rescue by viral delivery of Cabp2 identifies the interplay between two CaBPs to promote sustained synaptic transmission at the inner hair cell synapses.
    1. Immunology and Inflammation

    Gasdermin D-mediated neutrophil pyroptosis drives inflammation in psoriasis

    Jian Liu, YuYing Jiang ... ZhiQiang Yin
    Gasdermin D-mediated neutrophil pyroptosis plays an important role in driving inflammation in psoriasis, which unravels new pathogenesis of psoriasis and provides new insights into psoriasis treatment by targeting neutrophil pyroptosis.
    1. Genetics and Genomics

    Accurate predictions of SARS-CoV-2 infectivity from comprehensive analysis

    Jongkeun Park, WonJong Choi ... Dongwan Hong
    Big data analysis, protein structure prediction, and artificial intelligence are integrated to predict novel and highly transmissible SARS-CoV-2 variants.
    1. Neuroscience

    A multisite validation of brain white matter pathways of resilience to chronic back pain

    Mina Mišić, Noah Lee ... Herta Flor
    The structural integrity of the right superior longitudinal fasciculus was identified as a neuroimaging predictor of chronic back pain, with potential for clinical translation.