Browse our Research Articles

A single-cell transcriptomic study characterizes foxl2l-expressing germ cell progenitors important for female development in zebrafish and reveals the mechanism of sex differentiation.

Analyses of zebrafish meioc mutants revealed that spermatogonial stem cells with low rRNA transcription caused by nucleolar Piwil1 require Meioc to keep Piwil1 in cytoplasm for the upregulation of rRNA transcription necessary for differentiation.

Uncovering a novel PDE1A/YTHDF2/STAT3 pathway in non-small cell lung cancer (NSCLC) progression also provides therapeutic strategies for treating NSCLC patients with metastasis.

Genetic analysis of Streptococcus pyogenes reveals multiple mutations, including a key change in the fhuB gene, that influence the bacteria’s ability to cause severe invasive infections.

Coordinated removal of Tbx3 and Tbx5 function alters the molecular features of the fast ventricular cardiac conduction system toward non-conduction working myocardium, illuminating transcriptional control of cardiac conduction system patterning.

Endocardial id2b integrates biomechanical cues to orchestrate valve formation and myocardial maturation during cardiac development.

The Rho-ROCK–matriptase signaling axis promotes claudin release from EpCAM/TROP2 complexes, enabling tight junction reassembly during epithelial remodeling to preserve barrier integrity.

The BRAIN Circuits Program of the NIH BRAIN Initiative has impacted how fundamental discovery in integrative systems neuroscience is investigated, commensurate with the complexity to address neurobehavioral and neurological dysfunctions.

ABBA ensures proper cortical development by regulating radial glial division through RhoA activity at the cleavage furrow, and its mutation results in developmental abnormalities linked to microcephaly.

Failure in sexual behaviors suppresses sweet taste perception of male fruit flies, by dampening dopaminergic signaling between mating-related neural circuits and peripheral gustatory pathways.