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In a randomized trial, ART intensification by doubling the dolutegravir dosage in people with HIV stably suppressed on dolutegravir-based ART reduced levels of four HIV reservoir markers in peripheral blood.

Combining statistical modeling with flow cytometry enables reliable, high-throughput quantification of division asymmetry in live cells, revealing how partitioning noise may shape tumor cell heterogeneity.

Single-cell transcriptomic analysis of the murine testicular interstitium across the lifespan reveals Cd34⁺/Sox4⁺ mesenchymal cells as Leydig progenitors, whose aging-associated decline in glutathione and Sox4-regulated regenerative capacity inform potential therapeutic strategies for age-related testicular dysfunction.

Low-level features of peripheral saccade targets are fed back to early foveal retinotopic cortex in a signal that resembles activation elicited by direct foveal presentation.

Genetic and electrophysiological studies uncover a mechanism linking a TTN missense variant to atrial fibrillation by coupling titin with potassium channel remodeling, revealing FHL2 as a modulator and therapeutic target.

Identification of a nitric oxide-regulated transitional state of Müller glia reveals a key mechanism enabling neuronal regeneration in the injured vertebrate retina.

Clinically relevant Ω-loop mutations in PDC-3 reshape active-site dynamics to enhance β-lactamase activity, providing mechanistic insights that can guide the rational design of inhibitors.

Human cells decode dynamics Wnt signals using an anti-resonant filter that suppresses intermediate-frequency inputs and is capable of redirecting developmental fate outcomes, including germ-layer specification.

Single-cell transcriptomics identifies three discrete mouse trabecular meshwork subtypes and demonstrates that an Lmx1b glaucoma mutation drives mitochondrial dysfunction and elevated intraocular pressure, which is lessened by vitamin B3 supplementation.

ATAD2 orchestrates histone turnover during spermatogenesis, regulating H3.3 deposition, chromatin condensation, and genome packaging to ensure proper sperm genome organization and transcriptional control.