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The characteristic hexagonal firing pattern of grid cells emerges as the most parsimonious solution to a trajectory code by cell sequences.

Co-culture between donor-derived iPSC-induced macrophages and forebrain organoids revealed microglial impairment leading to the degenerative neuro-environment in HDLS.

For the first time, mouse models reveal the metabolic dependency of photoreceptors on glutamine catabolism in vivo and further demonstrate the flexibility of photoreceptors to utilize fuel sources beyond glucose.

Monocarboxylate transporter 1 overexpressed pancreatic cancers can be therapeutically targeted with ME3BP-7, a promising new agent with unique mode of action.

A computational study reveals that the kinetic models of Escherichia coli metabolism show strong responsiveness to perturbations and that it originates from cofactor dynamics and network sparsity.

The generation of a Ctla-4-deficient zebrafish line has established a direct link between Ctla-4 and IBD in zebrafish.

Secretory leukocyte protease inhibitor suppresses Borrelia burgdorferi infection-induced periarticular inflammation in mice by maintaining anti-protease–protease balance.

Caenorhabditis elegans FLWR-1/Flower is required for efficient synaptic vesicle recycling and does so through a functional and possibly direct physical interaction with the plasma membrane Ca²⁺ ATPase, MCA-3.

ALP alterations in Q175 brains are late-onset, mild, existing at the later phases of the pathway, and stimulating autophagy at early disease progression enhances mHTT clearance to ameliorate HD pathology.

A technique that enables single-particle cryo-EM analysis of targets on a magnetic bead and a particle curation method that helps structural classification of small particles has been developed.