AARS2 safeguards cardiomyocytes against ischemic injury by modulating PKM2-driven energy metabolism, revealing the AARS2-PKM2 axis as a previously unrecognized cardioprotective pathway in myocardial infarction.
Lili Karashchuk, Jing Shuang Li ... Bingni W Brunton
A model that simulates realistic fly walking uses an anatomically-inspired layered architecture to achieve robust walking, quantifying the tolerance of this circuit to sensorimotor delays.
Matthew Rosenblatt, Saloni Mehta ... Dustin Scheinost
Self-citation rates differed by geographic region, seniority, gender, and field, which may ultimately affect the perceived influence of authors in these subgroups in neuroscience literature.
Cody J Warren, Arturo Barbachano-Guerrero ... Sara L Sawyer
Resurrection of ancient forms of CD4 reveals how retroviruses have placed selective pressure on this gene in apes, acting to propagate infection-resistant alleles.
Chemical inhibition or genetic downregulation of glycogen synthase kinase-3 reprograms human monocyte-derived macrophages by enhancing their anti-inflammatory, homeostatic, and reparative functions.
Dendritic cell (DC)-derived IL-27 establishes CD4+ T cell bias against IFN-γ via STAT1 and epigenetics, linking thymic development to autoimmune mechanisms.
Structural and biochemical analyses suggest the association of homotrimeric CesAs of different isoforms into cellulose biosynthesis complexes via their class-specific regions.
Time-lapse analyses of millions of antibiotic-stressed Escherichia coli characterize the diverse single-cell dynamics of persister cells that depend on antibiotics, culture conditions, and pre-exposure history.
