Browse our Research Articles

Page 21 of 1,399
    1. Neuroscience

    Mapping serotonergic dynamics using drug-modulated molecular connectivity in rats

    Tudor M Ionescu, Mario Amend ... Kristina Herfert
    PET molecular connectivity is feasible, plausible, and delineates brain-wide pharmacologic effects not identified by BOLD functional connectivity.
    1. Cell Biology
    2. Developmental Biology

    Rudhira-mediated microtubule stability controls TGFβ signaling during mouse vascular development

    Divyesh Joshi, Preeti Jindal ... Maneesha S Inamdar
    The precise integration of endothelial TGFβ signaling and microtubule stability directs cardiovascular development.
    1. Cell Biology
    2. Medicine

    AARS2 ameliorates myocardial ischemia via fine-tuning PKM2-mediated metabolism

    Zongwang Zhang, Lixia Zheng ... Jing-Wei Xiong
    AARS2 safeguards cardiomyocytes against ischemic injury by modulating PKM2-driven energy metabolism, revealing the AARS2-PKM2 axis as a previously unrecognized cardioprotective pathway in myocardial infarction.
    1. Computational and Systems Biology
    2. Neuroscience

    Sensorimotor delays constrain robust locomotion in a 3D kinematic model of fly walking

    Lili Karashchuk, Jing Shuang Li ... Bingni W Brunton
    A model that simulates realistic fly walking uses an anatomically-inspired layered architecture to achieve robust walking, quantifying the tolerance of this circuit to sensorimotor delays.
    1. Neuroscience

    Trends in self-citation rates in high-impact neurology, neuroscience, and psychiatry journals

    Matthew Rosenblatt, Saloni Mehta ... Dustin Scheinost
    Self-citation rates differed by geographic region, seniority, gender, and field, which may ultimately affect the perceived influence of authors in these subgroups in neuroscience literature.
    1. Microbiology and Infectious Disease

    Adaptation of CD4 in gorillas and chimpanzees conveyed resistance to simian immunodeficiency viruses

    Cody J Warren, Arturo Barbachano-Guerrero ... Sara L Sawyer
    Resurrection of ancient forms of CD4 reveals how retroviruses have placed selective pressure on this gene in apes, acting to propagate infection-resistant alleles.
    1. Immunology and Inflammation

    Reprogramming of GM-CSF-dependent alveolar macrophages through GSK3 activity modulation

    Israel Ríos, Cristina Herrero ... Angel L Corbí
    Chemical inhibition or genetic downregulation of glycogen synthase kinase-3 reprograms human monocyte-derived macrophages by enhancing their anti-inflammatory, homeostatic, and reparative functions.
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    1. Immunology and Inflammation

    Thymic dendritic cell-derived IL-27p28 promotes the establishment of functional bias against IFN-γ production in newly generated CD4+ T cells through STAT1-related epigenetic mechanisms

    Jie Zhang, Hui Tang ... Yu Zhang
    Dendritic cell (DC)-derived IL-27 establishes CD4+ T cell bias against IFN-γ via STAT1 and epigenetics, linking thymic development to autoimmune mechanisms.
    1. Structural Biology and Molecular Biophysics

    Structure, function and assembly of soybean primary cell wall cellulose synthases

    Ruoya Ho, Pallinti Purushotham ... Jochen Zimmer
    Structural and biochemical analyses suggest the association of homotrimeric CesAs of different isoforms into cellulose biosynthesis complexes via their class-specific regions.
    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    Observation of persister cell histories reveals diverse modes of survival in antibiotic persistence

    Miki Umetani, Miho Fujisawa ... Yuichi Wakamoto
    Time-lapse analyses of millions of antibiotic-stressed Escherichia coli characterize the diverse single-cell dynamics of persister cells that depend on antibiotics, culture conditions, and pre-exposure history.