Browse our Research Articles

Page 246 of 1,376
    1. Cell Biology

    A single-cell transcriptome atlas of pig skin characterizes anatomical positional heterogeneity

    Qin Zou, Rong Yuan ... Yanzhi Jiang
    The heterogeneity in molecule and function of three main cell types of smooth muscle cells, endothelial cells, and fibroblasts from both different anatomical sites of pig skin was comprehensively exposited.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Genetic architecture of heart mitochondrial proteome influencing cardiac hypertrophy

    Karthickeyan Chella Krishnan, Elie-Julien El Hachem ... Aldons J Lusis
    The discovery of three distinct and independent trans-regulating genomic loci influencing heart mass using a well-characterized mouse reference population provides evidence in support of the hypothesis that genetic diversity in the mitochondrial proteome plays a critical role in heart pathophysiology.
    1. Stem Cells and Regenerative Medicine

    Microcephaly-associated protein WDR62 shuttles from the Golgi apparatus to the spindle poles in human neural progenitors

    Claudia Dell'Amico, Marilyn M Angulo Salavarria ... Marco Onorati
    Microcephaly-associated mutations disrupt microtubule-dependent WDR62 translocation from the Golgi complex to the mitotic spindle poles, impair mitotic progression, and alter neurogenic trajectories in patient induced Pluripotent Stem Cell-derived 2D and 3D models of human neurodevelopment.
    1. Epidemiology and Global Health

    Predictive performance of multi-model ensemble forecasts of COVID-19 across European nations

    Katharine Sherratt, Hugo Gruson ... Sebastian Funk
    A large collaborative project combined many different researchers' forecasts of COVID-19 across Europe, making predictions used in policy more reliable.
    1. Neuroscience

    Cholinergic and noradrenergic axonal activity contains a behavioral-state signal that is coordinated across the dorsal cortex

    Lindsay Collins, John Francis ... David A McCormick
    Cortical cholinergic and noradrenergic signaling contains a strong low-frequency component that is distributed across the mouse cortex and is related to the behavioral state of the animal.
    1. Computational and Systems Biology

    Shared enhancer gene regulatory networks between wound and oncogenic programs

    Swann Floc'hlay, Ramya Balaji ... Stein Aerts
    Single-cell multiomics reveals the gene regulatory networks and enhancer logic underlying two distinct wound response cell states in the Drosophila wing imaginal disc and finds similarities with cell states observed in the Ras-scrib tumor model.
    1. Neuroscience

    Early language exposure affects neural mechanisms of semantic representations

    Xiaosha Wang, Bijun Wang, Yanchao Bi
    Impoverished access to natural human language during early childhood reduces semantic structure encoding in the left dorsal anterior temporal lobe, which provides positive evidence for the role of language in forming specific neural semantic representations in the human brain.
    1. Neuroscience

    Two conserved vocal central pattern generators broadly tuned for fast and slow rates generate species-specific vocalizations in Xenopus clawed frogs

    Ayako Yamaguchi, Manon Peltier
    Although courtship vocalizations are unique to each species, the basic architecture of the neural circuitries underlying this behavior is conserved among closely related species of frogs, suggesting behavior can diverge while utilizing the homologous neural network inherited through evolutionary lineage.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Cohesin-independent STAG proteins interact with RNA and R-loops and promote complex loading

    Hayley Porter, Yang Li ... Suzana Hadjur
    STAG proteins function independently of core cohesin at R-loops to facilitate cohesin loading.
    1. Cancer Biology
    2. Computational and Systems Biology

    Comprehensive characterization of tumor microenvironment in colorectal cancer via molecular analysis

    Xiangkun Wu, Hong Yan ... Li Liang
    Integrated molecular analysis demonstrated that colorectal cancer can be classified into four molecular subtypes (proliferative, immunomodulatory, immunosuppressed, and immune-excluded subtypes), providing valuable insight into the intricate relationship between tumor microenvironment heterogeneity and various clinical phenotypes.