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The lysine/glutamic acid/arginine region in chromatin assembly factor (CAF-1) forms a long single alpha-helix DNA-binding domain, facilitating the recognition of tetrasome-length DNA and linking functional domains within the CAF-1 architecture for efficient tetrasome assembly after DNA synthesis.

Fish environmental DNA remaining in a cup of seawater provides information about interaction strengths among marine fish species in nature, highlighting the potential impact of global climate change on community dynamics and stability.

Electrophysiological study in human brain slices reveals that short-term synaptic plasticity from presynaptic pyramidal neuron to postsynaptic interneuron connections are target-cell specific based on their subclass interneuron identity.

Flies can optimally recall a memory with high specificity by comparing options close in time, or default to generalization when they cannot.

Hypoxia does not increase glycolysis in proliferating primary cells and antagonizes the increase in glycolysis caused by activation of hypoxia-inducible factor in normoxia, in part, through activation of MYC signaling pathways.

Changing substituents on the aromatic rings of polyunsaturated fatty acid analogues tailors their activation effect on the I_Ks channel and thus their therapeutic potential for long QT syndrome.

A road to modulators of the kinase activity and the non-enzymatic functions of Src and IDO1 at once.

Two flying squirrel species chewed grooves into Cyclobalanopsis nuts, and used them to pressure-fit nuts tightly in crotches formed by small twigs on understory plants, in a way similar to a mortise-tenon joint used in architecture and carpentry.

Regulation of phosphoinositide 3 kinase (PI3Kγ) is essential in immune function, and stimuli that modulate the dynamics of the PI3Kγ helical domain can activate or inhibit kinase activity.

Linguistic features are encoded more strongly during language comprehension than when comprehension is absent, and high word entropy (less constraining context) enhances the encoding of lower-level acoustic and linguistic features while low word entropy suppresses it.