σ28-Dependent sRNAs fine-tune flagella synthesis, with one sRNA connecting synthesis with metabolism and two sRNAs with opposing effects connecting synthesis with ribosomal protein production through unique binding within coding sequences.
Proteomic analysis of brain organoids from creatine transporter deficiency (CTD) patients enhance the understanding of CTD offering potential therapeutic targets and a robust foundation for continued research in the field.
The COVID Tissue Atlas Consortium, Alejandro A Granados ... Bruce Wang
A conserved transcriptional signature in macrophages and endothelial cells occurs in multiple organs in response to COVID-19 and suggests potential molecular interactions between the two cell types.
Frontal cortical circuit alterations and cognitive deficits identified in mouse genetic models are reversed by chemogenetic or optogenetic stimulation of the mesocortical dopamine circuit in an adolescent period.
Liang-Yu Pang, Steven DeLuca ... Allan C Spradling
Chromatin changes downstream from Drosophila germline stem cells and fertilized zygotes alter how transposable element activity and gene expression are controlled to facilitate differentiation.
Xenopus laevis arose from hybridization of two different frog species millions of years ago, leading to adaptation of the genetic networks controlling early embryonic development and stem cell induction to balance expression between the genes inherited from each ancestor.
Abhishek Jamwal, Cristina F Constantin ... Matthew K Higgins
The most effective growth-neutralising antibodies which target the PfRH5 protein from a malaria parasite function by preventing the parasite from binding to basigin-containing membrane protein complexes on human erythrocytes.
Márton A Simon, Iordan Iordanov ... László Csanády
Functional studies on CFTR anion channels harboring combinations of catalytic site mutations in the active ATPase site reveal the true stability of the prehydrolytic open-pore state as well as nucleotide-binding domain interface features that are unique to human CFTR.
Xarxa Quiroga, Nikhil Walani ... Pere Roca-Cusachs
Cell stretch release generates plasma membrane (PM) evaginations of ≈100 nm, triggering a local event of actin polymerization that flattens and recovers PM shape.
A reduction in breast screening participation volume during COVID-19 that differed by region and healthcare setting was observed in a rapid review of 26 studies globally, suggesting monitoring of screening access by disadvantaged groups to reduce disparities.
