A differentiable variant of the Gillespie algorithm enables gradient-based optimization for stochastic chemical kinetics, facilitating efficient parameter estimation and the design of biochemical networks with desired input–output relationships.
Foxg1 regulates gliogenesis in the mouse neocortex by modulating FGF signalling and integrating intrinsic and extrinsic mechanisms to ensure a balanced production of neurons, astrocytes, and oligodendrocytes in the brain.
The cell membrane receptors of juvenile hormone, CAD96CA and FGFR1, regulate the genomic effects of juvenile hormone by phosphorylating intracellular receptor.
A novel mouse model offers definitive evidence that a single inhibitory receptor family governs the critical natural killer cell functions of licensing and missing-self.
Differentiation of human pluripotent stem cells mutant for one GATA6 gene can model developmental heart defects seen in some patients with congenital heart disease.
RNA interference pathways are spatially and temporally organized during Caenorhabditis elegans embryogenesis, with the Argonaute protein NRDE-3 playing distinct roles in regulating genes in different cell types and developmental stages.
The gut microbiome regulates protein absorption activity in lysosome-rich enterocytes (LREs) and causes broad gene expression changes, while LRE activity also affects the microbiome.
