D2-like receptors in a pair of dopamine DAN-c1 neurons drive aversive learning, while those in mushroom body neurons mediate both aversive and appetitive learning in Drosophila larvae.
A time-course RNA-seq analysis of muscle remodeling reveals transcriptional dynamics independent of autophagy and highlights the significance of BNIP3 in mitochondrial degradation in vivo.
Marc W Schmid, Klara Kropivšek ... Ueli Grossniklaus
Strong selection by aphids only weakly affects epigenetic and phenotypic variation within three Arabidopsis thaliana accessions, demonstrating limited potential for adaptation by epigenetic differentiation within genotypes in this model species.
Anna Pakula, Salsabiel El Nagar ... Alexandra L Joyner
During cerebellum regeneration following injury, reactive oxygen species are implicated as enhancing the adaptive reprogramming response that contributes to replenishment of granule cell progenitors that are killed.
The combination of histological and microscopic techniques, along with the initial application of finite-difference time-domain (FDTD) modeling to a fossil feather, has resulted in the first recovery of specific iridescent color patterns.
Mendelian randomization offers novel insights into the genetic factors that influence the aging process through early-life reproductive events, providing robust evidence for the antagonistic pleiotropy theory in humans.
Irina Kalita, Ira Alexandra Iosub ... Meriem El Karoui
Single-molecule mRNA and protein quantification, combined with stochastic modelling, uncover a post-transcriptional regulatory mechanism that controls the expression of the extremely low-abundance DNA double-strand break repair enzyme RecBCD.
Depletion of Dynamin-related protein 1, a key regulator of mitochondrial fission, in mouse zygotes impair symmetric organelle partitioning and chromosome segregation leading to early developmental arrest.
