Browse our Research Articles

Page 26 of 1,434
    1. Cell Biology

    Hexokinase regulates Mondo-mediated longevity via the PPP and organellar dynamics

    Raymond Laboy, Marjana Ndoci ... Adam Antebi
    Hexokinases regulate the metabolic transcription factor MML-1 via distinct pathways, linking glucose metabolism and organellar signaling to longevity control in Caenorhabditis elegans and mammals.
    1. Microbiology and Infectious Disease

    A biofilm-tropic Pseudomonas aeruginosa bacteriophage uses the exopolysaccharide Psl as receptor

    Brenna Walton, Serena Abbodante ... Arne Rietsch
    Certain bacteriophage are specifically adapted to infecting biofilm bacteria by exploiting biofilm characteristics, such as the exopolysaccharides produced by bacteria in biofilms.
    1. Evolutionary Biology

    Recurrent mutations drive the rapid evolution of pesticide resistance in the two-spotted spider mite Tetranychus urticae

    Li-Jun Cao, Jin-Cui Chen ... Shu-Jun Wei
    The rapid development of pesticide resistance in a mite across wide geographical areas is linked to the independent and repeated emergence of multiple mutations in target genes.
    1. Cancer Biology

    Human multiethnic radiogenomics reveals low-abundancy microRNA signature in plasma-derived extracellular vesicles for early diagnosis and molecular subtyping of pancreatic cancer

    Jianying Xu, Wenjie Shi ... Ulf Dietrich Kahlert
    A novel, non-invasive strategy combining radiomics and blood extracellular vesicle-derived microRNA profiling to sharpen pancreatic cancer diagnosis is introduced.
    1. Developmental Biology

    Molecular and mechanical signatures contributing to mouse epidermal differentiation and barrier formation

    Alexandra Prado-Mantilla, Wenxiu Ning, Terry Lechler
    The roles of intermediate cells and contractility are characterized in the embryonic development of the epidermis.
    1. Microbiology and Infectious Disease

    Lacticaseibacillus rhamnosus P118 enhances host tolerance to Salmonella infection by promoting microbe-derived indole metabolites

    Baikui Wang, Xianqi Peng ... Min Yue
    Probiotic P118 against Salmonella infections by directly antibacterial actions, inhibiting Salmonella colonization and invasion, attenuating macrophage pro-inflammatory responses, and modulating gut microbiota mediated by microbe-derived indole metabolites.
    1. Developmental Biology

    Identification and characterization of early human photoreceptor states and cell-state-specific retinoblastoma-related features

    Dominic WH Shayler, Kevin Stachelek ... David Cobrinik
    Full-length single-cell RNA-sequencing provide insights into the earliest gene expression programs, the distinct mRNA transcript isoforms, and the retinoblastoma-related cell states associated with human cone and rod photoreceptor development.
    1. Structural Biology and Molecular Biophysics

    Simulation-based survey of TMEM16 family reveals that robust lipid scrambling requires an open groove

    Christina Alexandra Stephens, Niek van Hilten ... Michael Grabe
    The majority of TMEM16 lipid scrambling occurs in the open groove associated with Ca2+ activation, but limited scrambling also occurs in the dimer interface independent of Ca2+.
    1. Developmental Biology

    Cytoneme-mediated intercellular signaling in keratinocytes is essential for epidermal remodeling in zebrafish

    Yi Wang, Thomas Nguyen ... Dae Seok Eom
    Keratinocyte cytonemes mediate essential Notch signaling for proper skin maintenance, with their disruption leading to abnormal differentiation and hyperproliferation resembling human skin disease phenotypes.
    1. Medicine
    2. Neuroscience

    Acute aerobic exercise intensity does not modulate pain potentially due to differences in fitness levels and sex effects: results from a pharmacological fMRI study

    Janne Ina Nold, Tahmine Fadai, Christian Büchel
    Exercise intensity alone does not differentially reduce pain, but individual factors like fitness level and sex, along with opioid mechanisms, may influence exercise-induced pain relief.