Browse our Research Articles

Page 257 of 1,392
    1. Immunology and Inflammation

    Neuron-associated macrophage proliferation in the sensory ganglia is associated with peripheral nerve injury-induced neuropathic pain involving CX3CR1 signaling

    Rafaela M Guimarães, Conceição E Aníbal-Silva ... Thiago M Cunha
    CX3CR1-signaling in sensory ganglia macrophages mediates their proliferation/activation, as well as the production of pro-inflammatory mediators that contribute to neuropathic pain.
    1. Cell Biology
    2. Physics of Living Systems

    Physical basis of the cell size scaling laws

    Romain Rollin, Jean-François Joanny, Pierre Sens
    A theoretical model explains how protein density and nuclear to cell volume ratio are maintained during cell growth, discusses conditions under which this breaks down, and highlights the importance of metabolites, mainly amino acids such as glutamate, in this homeostasis.
    1. Neuroscience

    Role of the postinspiratory complex in regulating swallow–breathing coordination and other laryngeal behaviors

    Alyssa Huff, Marlusa Karlen-Amarante ... Jan-Marino Ramirez
    The postinspiratory complex acts as an interface between the swallow pattern generator and the preBötzinger complex to coordinate swallow and breathing.
    1. Microbiology and Infectious Disease
    2. Immunology and Inflammation

    Cellular and molecular dynamics in the lungs of neonatal and juvenile mice in response to E. coli

    Sharon A McGrath-Morrow, Jarrett Venezia ... Alan L Scott
    A pre-clinical model of E. coli pneumonia reveals attenuated dynamics of MHCII-expressing mononuclear cells in neonatal lung associated with elevated susceptibility to bacterial pneumonia.
    1. Neuroscience

    Concurrent decoding of distinct neurophysiological fingerprints of tremor and bradykinesia in Parkinson’s disease

    Peter M Lauro, Shane Lee ... Wael F Asaad
    Motor signs of Parkinson’s disease such as tremor and bradykinesia are independently expressed and exhibit distinct signatures of neural activity that can independently decoded from subthalamic and cortical recordings using interpretable machine learning.
    1. Structural Biology and Molecular Biophysics

    Biological condensates form percolated networks with molecular motion properties distinctly different from dilute solutions

    Zeyu Shen, Bowen Jia ... Mingjie Zhang
    Molecules in the condensed phase of biological condensates convert between transiently confined states and mobile states by forming dynamic percolated networks.
    1. Genetics and Genomics
    2. Neuroscience

    Belly roll, a GPI-anchored Ly6 protein, regulates Drosophila melanogaster escape behaviors by modulating the excitability of nociceptive peptidergic interneurons

    Kai Li, Yuma Tsukasa ... Tadao Usui
    Belly roll, Bero, an Ly6/α-neurotoxin family protein, is identified as a critical modulator of peptidergic interneurons in Drosophila melanogaster, shedding light on genetic regulations of nociceptive escape behaviors and providing a potential target for future studies on pain perception.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    The Dantu blood group prevents parasite growth in vivo: Evidence from a controlled human malaria infection study

    Silvia N Kariuki, Alexander W Macharia ... Thomas N Williams
    Strongly protective effect conferred by the Dantu blood group variant against early, non-clinical, Plasmodium falciparum malaria infections in vivo.
    1. Neuroscience

    A descending inhibitory mechanism of nociception mediated by an evolutionarily conserved neuropeptide system in Drosophila

    Izumi Oikawa, Shu Kondo ... Ken Honjo
    Descending inhibition of nociception from the brain has been identified in Drosophila larvae, for the first time in non-mammalian organisms.
    1. Evolutionary Biology

    Femora from an exceptionally large population of coeval ornithomimosaurs yield evidence of sexual dimorphism in extinct theropod dinosaurs

    Romain Pintore, Raphaël Cornette ... Ronan Allain
    Consistent bimodal variations in the femoral morphology of various modern amniotes and a remarkably large herd of coeval fossil non-avian theropods evidences sexual dimorphism in dinosaurs.