Browse our Research Articles

Page 258 of 1,418
    1. Neuroscience

    Sex-dependent noradrenergic modulation of premotor cortex during decision-making

    Ellen M Rodberg, Carolina R den Hartog ... Elena M Vazey
    Female rats express higher levels of β noradrenergic receptor RNA in premotor cortex than males, and systemic blockade of these receptors diminished neural representation of action plans in premotor cortex and impaired decision-making performance, especially in females.
    1. Epidemiology and Global Health
    2. Medicine

    Direct economic burden of mental health disorders associated with polycystic ovary syndrome: Systematic review and meta-analysis

    Surabhi Yadav, Olivia Delau ... Ricardo Azziz
    Polycystic ovary syndrome (PCOS) is a highly prevalent disorder of women, with significant reproductive, endocrine, and metabolic morbidities and a total healthcare-related economic burden exceeding $15 billion (2021 USD) for the U.S. alone, $4 billion due to mental health disorders.
    1. Medicine

    Electronic data review, client reminders, and expanded clinic hours for improving cervical cancer screening rates after the COVID-19 pandemic shutdowns: A multicomponent quality improvement program

    Sue Ghosh, Jackie Fantes ... Rebecca B Perkins
    The largest federally qualified health center in Massachusetts was able to improve cervical cancer screening rates during the COVID-19 pandemic by creating clinical sessions devoted only to screenings.
    1. Neuroscience

    Age-related differences in the functional topography of the locus coeruleus and their implications for cognitive and affective functions

    Dániel Veréb, Mite Mijalkov ... Joana B Pereira
    A gradient-based approach is employed to characterize the organization of functional connectivity in the human locus coeruleus, revealing age-related differences and associations with cognitive and affective functions independently from age.
    1. Cancer Biology

    Isoform-specific disruption of the TP73 gene reveals a critical role for TAp73γ in tumorigenesis via leptin

    Xiangmudong Kong, Wensheng Yan ... Xinbin Chen
    Mouse model reveals that TAp73γ functions as an oncogene to promote tumorigenesis and alter lipid metabolism by modulating leptin expression.
    1. Cell Biology

    The negative adipogenesis regulator Dlk1 is transcriptionally regulated by Ifrd1 (TIS7) and translationally by its orthologue Ifrd2 (SKMc15)

    Ilja Vietor, Domagoj Cikes ... Lukas A Huber
    Ifrd1 and Ifrd2 were identified using knockout mice as new molecular players regulating via two discrete mechanisms the activity of the transcriptional regulator Dlk1 and thereby affecting adipocyte differentiation.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    CaMKII autophosphorylation can occur between holoenzymes without subunit exchange

    Iva Lučić, Léonie Héluin ... Andrew JR Plested
    CaMKII is capable of spreading activity between holoenzymes without exchanging subunits.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Imprinted Dlk1 dosage as a size determinant of the mammalian pituitary gland

    Valeria Scagliotti, Maria Lillina Vignola ... Marika Charalambous
    Pituitary gland size and stem cell number is modulated during early life in the mouse by the imprinted gene Dlk1, which acts in multiple developmental compartments in a dosage-sensitive manner.
    1. Chromosomes and Gene Expression

    A local ATR-dependent checkpoint pathway is activated by a site-specific replication fork block in human cells

    Sana Ahmed-Seghir, Manisha Jalan ... Simon N Powell
    Cells exhibit a localized ATR-dependent DNA damage response to a site-specific stalled replication fork that is distinct from that observed after global replication stress.
    1. Genetics and Genomics
    2. Immunology and Inflammation

    CD8+ tissue-resident memory T cells induce oral lichen planus erosion via cytokine network

    Maofeng Qing, Dan Yang ... Qianming Chen
    CD8+ Trm cells' erosion role in oral lichen planus via IFN-γ, TNF-α, and IL17 cytokines has been revealed, addressing a gap in recurrent erosion studies.