The N-terminally truncated Δ133p53α and Δ160p53α isoforms exert dominant-negative effects through co-aggregation with p53, disrupting its transcriptional activity and cellular distribution, thereby contributing to cancer development.
Animals may learn to locate preys effectively by memorizing short excerpts of their scent trace, which duration is dictated by the sparse nature of turbulent odor plumes.
Saima Usman, William Andrew Yeudall ... Ahmad Waseem
Disruption of vimentin–actin interaction induces XIST expression and drives epithelial-to-mesenchymal transition and stem cell-like traits in breast cancer cells, enhancing oncogenic behaviour in nude mice independent of oestrogen.
A pioneering Bolivian seroepidemiological study employed innovative serological and neutralization assays as highly effective complements to genomic surveillance, delivering critical insights into SARS-CoV-2 variant circulation and informing public health strategies.
Charles-francois V Latchoumane, Joon-Hyuk Lee ... Hee-Sup Shin
The firing mode of mediodorsal thalamic neurons may act as a central switching mechanism for the level of arousal and consciousness in natural sleep and induced ethanol hypnosis in mice.
Genetic analyses of rare non-mosaic females define X-inactivation status for 380 genes and uncover widespread X-chromosome skewing in the general population, providing insights into sex-biased traits and X-linked disease expression.
In vision-based flight control of hummingbird hawkmoths, the visual field partitions by natural cue prevalence into an optic flow and dorsal directional pathway, which integrate according to their relevance for flight safety.
