Browse our Research Articles

Structure-based designed chalcone and pyrazoline derivatives inhibited the ELF3-MED23 protein-protein interaction, leading to HER2 downregulation and retardation of tumor growth in HER2-positive gastric cancer.

A revised analytical framework grounded in the principle of binomial distribution captures the full clonality and dynamic shifts of hematopoiesis throughout ontogeny.

The minimal twister sister (TS)-like self-cleaving ribozymes, revealed by deep mutational scanning, represent some of the very few human/primate ribozymes.

FipA is a novel component required for bacteria that rely on FlhF/FlhG to properly localize their flagella to the cell pole.

Stress-regulated secretion of an intestinal peptide positively regulates the antioxidant response by promoting neuropeptide release from the nervous system, defining a gut-to-brain-to-gut endocrine axis in the oxidative stress response.

A novel deep-learning-based computational method using object recognition to quantify visual context in naturalistic, multimodal stimuli demonstrates that a concept's perceived abstractness or concreteness dynamically depends on its visual context.

Continuous attractor networks can constrain population activity to manifolds with topology radically different from that of the network architecture.

The PfMORC protein is proven to play a crucial role in chromatin structure, gene regulation and heterochromatin stability, categorizing PfMORC as a strong potential candidate for novel therapeutic interventions.

The importance of the αC-β4 loop at the interface between the N- and C-lobes of Protein Kinase A for synergistic high-affinity binding of ATP and a pseudo substrate inhibitor.

Differential colonization-extinction dynamics associated with species thermal preferences provide support for dispersal limitation and microclimate buffering as primary proxies by which habitat fragmentation mediates thermophilization in birds.