Niklas Lonnemann, Shirin Hosseini ... Martin Korte
Expression of an interleukin that is immune suppressive (IL-37) in mice is able to limit inflammation in the brain after acute inflammatory events and prevent loss of cognitive abilities in a mouse model of AD.
Animal experiments show that the mosaic-type immunogen integrating key mutations from Omicron and other circulating variants elicits broad neutralization against divergent SARS-CoV-2 strains.
By analysing large-scale datasets from the Allen Brain Observatory, we found that changes in the behavioural state of the animal can significantly contribute to the changes in representational similarity over time.
Nicholas A Donnelly, Ullrich Bartsch ... Matt W Jones
Measures of sleep features such as spindles and slow waves differentiate between young people with 22q11.2 microdeletion syndrome and healthy controls, and may mediate the relationship between this genotype and psychiatric symptoms.
The early influence of the breakdown of both hippocampal structural network and angular gyrus-seeded default mode metabolism network on memory performance underscore the importance of early intervention in preclinical Alzheimer’s disease.
Nuria Vilaplana-Lopera, Vincent Cuminetti ... Paloma Garcia
Interplay between AML and stromal cells can initiate a mechanism involving gap junctions where ROS is transferred from cancer cells to stromal cells which then produce acetate which can in return be absorbed/utilised by the cancer cells.
Brad K Hulse, Hannah Haberkern ... Vivek Jayaraman
An analysis of the first complete synaptic resolution connectome of Drosophila's navigation circuit uncovers neural network motifs supporting broadly relevant sensorimotor computations.
Dawn M Wenzel, Douglas R Mackay ... Wesley I Sundquist
A comprehensive, quantitative, protein-protein interaction screen maps the network of interactions between human MIT domains and ESCRT-III C-terminal tails, and reveals MIT domain-containing protein cofactors for abscission and the 'No Cut' abscission checkpoint.
The muscle circadian clock regulates RNA-binding motif 20 (Rbm20) gene expression, providing a novel mechanism for titin splicing and isoform expression with implications for muscle structure and function.
A cryo-EM structure of the bacterial OmcZ cytochrome filament provides evidence for the possibility that cytochrome polymers had multiple origins in bacteria.
