Browse our Research Articles

Page 376 of 1,392
    1. Cell Biology
    2. Neuroscience

    Chronic neurotransmission increases the susceptibility of lateral-line hair cells to ototoxic insults

    Daria Lukasz, Alisha Beirl, Katie Kindt
    In vivo imaging reveals that the synaptic vesicle cycle is a significant contributor to oxidative stress in sensory hair cells, rendering them susceptible to insults.
    1. Ecology

    Experimental evidence that chronic outgroup conflict reduces reproductive success in a cooperatively breeding fish

    Ines Braga Goncalves, Andrew N Radford
    Outgroup conflict can negatively impact general reproductive behaviour, egg investment, and parental care, resulting in decreased reproductive output even in the absence of physical confrontations.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Membrane-mediated dimerization potentiates PIP5K lipid kinase activity

    Scott D Hansen, Albert A Lee ... Jay T Groves
    Dimerization promotes nonlinear kinetics in PIP5K-dependent lipid phosphorylation reactions.
    1. Genetics and Genomics

    Association analyses of host genetics, root-colonizing microbes, and plant phenotypes under different nitrogen conditions in maize

    Michael A Meier, Gen Xu ... Jinliang Yang
    Comprehensive analyses of host genetics, root-associated microbiomes, and plant phenotypes under two nitrogen treatments reveals host genetic control of microbe abundance which, in turn, affects plant performance.
    1. Evolutionary Biology

    Tradeoff breaking as a model of evolutionary transitions in individuality and limits of the fitness-decoupling metaphor

    Pierrick Bourrat, Guilhem Doulcier ... Katrin Hammerschmidt
    A new model describes evolutionary transitions in individuality in terms of tradeoff and tradeoff-breaking events as opposed to changes in the nature of fitness.
    1. Microbiology and Infectious Disease

    Innate immune signaling in trophoblast and decidua organoids defines differential antiviral defenses at the maternal-fetal interface

    Liheng Yang, Eleanor C Semmes ... Carolyn B Coyne
    Organoids developed from matched human placental tissue define differences in antiviral signaling between cell types comprising the maternal-fetal interface.
    1. Neuroscience

    Local field potentials reflect cortical population dynamics in a region-specific and frequency-dependent manner

    Cecilia Gallego-Carracedo, Matthew G Perich ... Juan Álvaro Gallego
    There is a frequency-dependent association between the local field potential and the coordinated activity of populations of single neurons, which remains constant during different aspects of behaviour but changes across regions of primate sensorimotor cortex.
    1. Neuroscience

    Controllability boosts neural and cognitive signatures of changes-of-mind in uncertain environments

    Marion Rouault, Aurélien Weiss ... Valentin Wyart
    Task controllability manipulations reveal that information seeking is associated with reduced confidence and active hypothesis testing, as well as stronger neurophysiological correlates of attention and arousal.
    1. Neuroscience

    Neural effects of continuous theta-burst stimulation in macaque parietal neurons

    Maria C Romero, Lara Merken ... Marco Davare
    Electrophysiological recordings in awake behaving monkeys show the first evidence of the effect of continuous theta-burst stimulation, a widely used repetitive transcranial magnetic stimulation protocol, at the level of single neurons.
    1. Microbiology and Infectious Disease

    Genetic and chemical validation of Plasmodium falciparum aminopeptidase PfA-M17 as a drug target in the hemoglobin digestion pathway

    Rebecca CS Edgar, Ghizal Siddiqui ... Tania F de Koning-Ward
    Plasmodium falciparum aminopeptidase PfA-M17 is essential to parasite survival and plays a role in hemoglobin digestion, providing a rationale for further development of inhibitors against this enzyme.