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Loss of nonstationary connectivity in a subcortical fronto-temporoparietal network distinguishes patients with minimal conscious state and unresponsive wakefulness state, strongly supporting the mesocircuit hypothesis.

The IgG4 subclass, previously considered anti-inflammatory due to its weak effector function, could either reduce or exacerbate autoantibody pathogenicity in the context of different IgG4-mediated autoimmune diseases.

Increased root exudation rate under combined drought and bacterial inoculation and bacterial growth stimulation by specific exudation metabolites support the idea of root recruitment of beneficial bacteria, especially under water stress.

The speed of replisomes in Escherichia coli depends on temperature and varies along the genome in a wave-like manner, with implications for bacterial physiology.

Human brain suggests an asymmetric organization along a functional cortical axis describing a hierarchical functional trajectory from perceptual/action to abstract cognition, which is heritable and comparable with macaque brain, suggesting (phylo)genetic conservation and adaptation.

Activation of Tacr1-expressing neurons including ON cells in the rostral ventromedial medulla inhibits acute and chronic itch-related behavior.

Fruit consumption of Jeholornis was evidenced and indicates seed dispersal was present from early in avian radiation.

In neurodegeneration of Gaucher disease, glucosylceramides trigger neuroinflammation via attrition of homeostatic microglia and transition to lipid-laden damage-associated microglia concurrently with infiltration of diverse immune cells including activated NK cells and CCR2⁺ macrophages, ameliorated by substrate reduction therapy.

Lack of cardiac MKK6 results in premature death with the development of heart hypertrophy and cardiac dysfunction in aging.

Zika virus infection induces the gasdermin E-mediated pyroptosis in placental cells through TNF-α-caspase-8-caspase-3 signaling pathway, which contributes to adverse fetal outcomes in pregnant mouse model.