Browse our Research Articles

Page 424 of 1,394
    1. Neuroscience

    Higher-order olfactory neurons in the lateral horn support odor valence and odor identity coding in Drosophila

    Sudeshna Das Chakraborty, Hetan Chang ... Silke Sachse
    Two-photon functional imaging linked to olfactory preference in Drosophila provides the first understanding of how odors are integrated, transformed, and represented in the lateral horn by an ensemble of higher-order glutamatergic lateral horn neurons.
    1. Computational and Systems Biology
    2. Neuroscience

    Electrocorticography is superior to subthalamic local field potentials for movement decoding in Parkinson’s disease

    Timon Merk, Victoria Peterson ... Wolf-Julian Neumann
    Advanced machine learning based brain signal decoding of grip-force as a proxy for movement vigor shows Parkinson's disease related performance reduction, suggestive of a loss of cortical vigor encoding in the absence of dopamine.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    CREB5 reprograms FOXA1 nuclear interactions to promote resistance to androgen receptor-targeting therapies

    Justin H Hwang, Rand Arafeh ... William C Hahn
    A comprehensive molecular interrogation of CREB5 interactions identified changes in protein and chromatin interactions of FOXA1 that promoted therapy resistance in prostate cancer cells.
    1. Cancer Biology
    2. Computational and Systems Biology

    Regulation of protein complex partners as a compensatory mechanism in aneuploid tumors

    Gökçe Senger, Stefano Santaguida, Martin H Schaefer
    Coordinated regulation of co-complex members compensates for aneuploidy-induced stoichiometric imbalances in human cancer.
    1. Immunology and Inflammation
    2. Neuroscience

    Single-cell profiling reveals periventricular CD56bright NK cell accumulation in multiple sclerosis

    Sabela Rodríguez-Lorenzo, Lynn van Olst ... Helga E de Vries
    Together, our multi-tissue single-cell data shows that CD56bright NK cells accumulate in the periventricular brain regions of multiple sclerosis (MS) patients, bringing NK cells back to the spotlight of MS pathology.
    1. Cell Biology

    CLUH controls astrin-1 expression to couple mitochondrial metabolism to cell cycle progression

    Désirée Schatton, Giada Di Pietro ... Elena I Rugarli
    CLUH links growth signaling pathways and mitochondrial metabolism with cell cycle progression by regulating astrin-1 synthesis and stability.
    1. Neuroscience

    Eye movements reveal spatiotemporal dynamics of visually-informed planning in navigation

    Seren Zhu, Kaushik J Lakshminarasimhan ... Dora E Angelaki
    The spatial and temporal patterns of eye movements exhibited by humans in virtual reality reveal how they plan paths when navigating in complex, naturalistic environments.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Hybridization alters the shape of the genotypic fitness landscape, increasing access to novel fitness peaks during adaptive radiation

    Austin H Patton, Emilie J Richards ... Christopher H Martin
    Hybridization not only generates genetic diversity, but this diversity can alter the shape of the fitness landscape, changing which genotypic combinations are favored by natural selection and which accessible genotypic paths lead to novel fitness peaks.
    1. Chromosomes and Gene Expression
    2. Immunology and Inflammation

    Binary outcomes of enhancer activity underlie stable random monoallelic expression

    Djem U Kissiov, Alexander Ethell ... David H Raulet
    Evidence that enhancer strength determines the extent of random monoallelic gene expression, and that even lineage defining genes thought to be expressed by all cells in a lineage display some degree of random monoallelic expression.
    1. Computational and Systems Biology

    Toward the cellular-scale simulation of motor-driven cytoskeletal assemblies

    Wen Yan, Saad Ansari ... Michael Shelley
    aLENS implements new parallel methods to resolve cytoskeletal assembly dynamics with high stability, physical consistency, and scalability.